期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 101, 期 3, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2022.151252
关键词
Aquaporins; Hearing impairment; Cochlea; Spiral ganglion; Stria vascularis
类别
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeioamento de Pessoal de Nivel Superior, Brazil (CAPES)
- Fundacao de Amparo a ` Pesquisa do Estado do Rio de Janeiro, Brazil (FAPERJ)
The inner ear, along with peripheral and central auditory pathways, plays a crucial role in hearing processing. Aquaporins (AQP) are integral membrane proteins that regulate water and ionic flow in the inner ear, and their expression changes are essential to auditory physiology and pathophysiological processes.
The inner ear is composed by tiny and complex structures that, together with peripheral and central auditory pathways, are responsible for hearing processing. However, not only the anatomy of the cochlea, its compartments and related structures are complex. The mechanisms involved in the regulation of homeostasis in the inner ear fluid, which determines the ionic gradient necessary for hearing and balancing sensory excitability, is an intricate phenomenon that involves several molecules. Among them, Aquaporins (AQP) play a significant role in this process. AQP are part of a family of small, integral membrane proteins that regulate different processes, including bidirectional water and ionic flow in the inner ear. Changes in the expression of these proteins are essential to auditory physiology and several pathophysiological processes in the inner ear. This review focuses on the role of AQP in health and disease of the auditory system.
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