4.7 Review

Adverse events in the placebo arm of maintenance therapy trials in advanced ovarian cancer: A systematic review and meta-analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase III trial

X. H. Wu et al.

Summary: This study demonstrated that maintenance treatment with niraparib significantly reduced the risk of disease progression or death in patients with platinum-sensitive recurrent ovarian cancer, and prolonged progression-free survival compared to placebo. Individualized dosing of niraparib was found to be effective and safe, and should be considered standard practice in this setting.

ANNALS OF ONCOLOGY (2021)

Article Oncology

Molecular and clinical predictors of improvement in progression-free survival with maintenance PARP inhibitor therapy in women with platinum-sensitive, recurrent ovarian cancer: A meta-analysis

Chee Khoon Lee et al.

Summary: In platinum-sensitive, recurrent, high-grade ovarian cancer, maintenance PARPi therapy improves progression-free survival for all patient subsets. PARPi therapy has a similar magnitude of benefit for somatic BRCA mutation and germline BRCA mutation patients. Although patients with BRCA mutations derive the greatest benefit, the absence of a BRCA mutation or HRD cannot be used to exclude patients from maintenance PARPi therapy.

CANCER (2021)

Article Oncology

Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial

Andres Poveda et al.

Summary: Olaparib provided a median overall survival benefit of 12.9 months compared with placebo in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation. Although statistical significance was not reached, these findings are arguably clinically meaningful and support the use of maintenance olaparib in these patients.

LANCET ONCOLOGY (2021)

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Oncology

Development and validation of the measure of ovarian symptoms and treatment concerns for surveillance (MOST-S26): An instrument to complement the clinical follow-up of women with ovarian cancer after completion of first-line treatment

Rachel Campbell et al.

Summary: The study developed and validated the MOST-S26 for surveillance of women in follow-up after first-line chemotherapy for OC. MOST-S26 reliably detected improvement in symptoms of peripheral neuropathy, psychological distress, and may detect symptoms of relapse. Administration of MOST-S26 in follow-up consultations could identify concerning symptoms and facilitate timely and appropriate intervention.

GYNECOLOGIC ONCOLOGY (2021)

Article Oncology

Molecular and clinical predictors of improvement in progression-free survival with maintenance PARP inhibitor therapy in women with platinum-sensitive, recurrent ovarian cancer: A meta-analysis

Chee Khoon Lee et al.

Summary: In platinum-sensitive, recurrent, high-grade ovarian cancer, maintenance PARPi therapy improves progression-free survival for all patient subsets. Patients with BRCA mutation derive the greatest benefit, but the absence of a BRCA mutation or HRD does not exclude patients from receiving maintenance PARPi therapy.

CANCER (2021)

Review Obstetrics & Gynecology

Latest clinical evidence of maintenance therapy in ovarian cancer

Christine S. Walsh

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY (2020)

Review Oncology

It is not just the drugs that matter: the nocebo effect

Marek Z. Wojtukiewicz et al.

CANCER AND METASTASIS REVIEWS (2019)

Article Medicine, General & Internal

Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

A. Gonzalez-Martin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Oncology

Ovarian Cancer Statistics, 2018

Lindsey A. Torre et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Article Obstetrics & Gynecology

Cancer of the ovary, fallopian tube, and peritoneum

Jonathan S. Berek et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2018)

Article Medicine, General & Internal

Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

K. Moore et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Endocrinology & Metabolism

The placebo effect in thyroid cancer: a meta-analysis

Maria Llavero-Valero et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2016)

Article Medicine, General & Internal

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

M. R. Mirza et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Pharmacology & Pharmacy

The nocebo effect of drugs

Sara Planes et al.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2016)

Article Oncology

Incorporation of Pazopanib in Maintenance Therapy of Ovarian Cancer

Andreas du Bois et al.

JOURNAL OF CLINICAL ONCOLOGY (2014)

Review Medicine, General & Internal

Assessing Bias in Studies of Prognostic Factors

Jill A. Hayden et al.

ANNALS OF INTERNAL MEDICINE (2013)

Article Medicine, General & Internal

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

Jonathan Ledermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Oncology

Oregovomab Maintenance Monoimmunotherapy Does Not Improve Outcomes in Advanced Ovarian Cancer

Jonathan Berek et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)