相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping
Isabel Weisheit et al.
NATURE PROTOCOLS (2021)
Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Dries A. M. Feyen et al.
CIRCULATION (2021)
The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy
Ray E. Hershberger et al.
CIRCULATION RESEARCH (2021)
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease
Kevin Eade et al.
NATURE METABOLISM (2021)
Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease
Juliette Le Douce et al.
CELL METABOLISM (2020)
The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure
Rachit Badolia et al.
CIRCULATION (2020)
Simple Lithography-Free Single Cell Micropatterning using Laser-Cut Stencils
Soah Lee et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2020)
Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
Wesley L. McKeithan et al.
CELL STEM CELL (2020)
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
Dries A. M. Feyen et al.
CELL REPORTS (2020)
A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy
Aviva Levitas et al.
PLOS GENETICS (2020)
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/l Deficiency Promotes Neuroendocrine Prostate Cancer
Miguel Reina-Campos et al.
CANCER CELL (2019)
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo
Lorna R. Fiedler et al.
CELL STEM CELL (2019)
Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association
Emelia J. Benjamin et al.
CIRCULATION (2019)
Assessing the causal association of glycine with risk of cardio-metabolic diseases
Laura B. L. Wittemans et al.
NATURE COMMUNICATIONS (2019)
Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications
Idit Goldfracht et al.
ACTA BIOMATERIALIA (2019)
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy
Jaecheol Lee et al.
NATURE (2019)
Role of Targeted Therapy in Dilated Cardiomyopathy: The Challenging Road Toward a Personalized Approach
Job A. J. Verdonschot et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)
Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy
Sarah R. Clippinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes
Yuichi Horikoshi et al.
CELLS (2019)
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy
Marin L. Gantner et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay
Timon Seeger et al.
CIRCULATION (2019)
Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes
Chris McDermott-Roe et al.
JCI INSIGHT (2019)
Rapid and effective response of the R222Q SCN5A to quinidine treatment in a patient with Purkinje-related ventricular arrhythmia and familial dilated cardiomyopathy: a case report
Joanna Zakrzewska-Koperska et al.
BMC MEDICAL GENETICS (2018)
Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function
Laura Padron-Barthe et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)
One-carbon metabolism markers are associated with cardiometabolic risk factors
M. V. Lind et al.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2018)
Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism
Xia Gao et al.
CELL REPORTS (2018)
Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells
Stephanie Lucas et al.
LIFE SCIENCE ALLIANCE (2018)
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Pedro M. Quiros et al.
JOURNAL OF CELL BIOLOGY (2017)
PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer
Song Gao et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)
Genome-wide analyses identify common variants associated with macular telangiectasia type 2
Thomas S. Scerri et al.
NATURE GENETICS (2017)
Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease
Patrick A. Eyers et al.
TRENDS IN CELL BIOLOGY (2017)
Dilated Cardiomyopathy Genetic Determinants and Mechanisms
Elizabeth M. McNally et al.
CIRCULATION RESEARCH (2017)
Classification, Epidemiology, and Global Burden of Cardiomyopathies
William J. McKenna et al.
CIRCULATION RESEARCH (2017)
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective
Ivana Celardo et al.
CELL DEATH AND DIFFERENTIATION (2017)
One-Carbon Metabolism in Health and Disease
Gregory S. Ducker et al.
CELL METABOLISM (2017)
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
Gregory S. Ducker et al.
CELL METABOLISM (2016)
Disease modelling using human iPSCs
Stormy J. Chamberlain
HUMAN MOLECULAR GENETICS (2016)
The importance of serine metabolism in cancer
Katherine R. Mattaini et al.
JOURNAL OF CELL BIOLOGY (2016)
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Maxim V. Kuleshov et al.
NUCLEIC ACIDS RESEARCH (2016)
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Eric M. Green et al.
SCIENCE (2016)
Serine one-carbon catabolism with formate overflow
Johannes Meiser et al.
SCIENCE ADVANCES (2016)
Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials
C. Kang et al.
SCIENTIFIC REPORTS (2016)
Serine and one-carbon metabolism in cancer
Ming Yang et al.
NATURE REVIEWS CANCER (2016)
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Insights Into Molecular, Cellular, and Functional Phenotypes
Ioannis Karakikes et al.
CIRCULATION RESEARCH (2015)
A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways
Ana P. Gomes et al.
CURRENT OPINION IN BIOTECHNOLOGY (2015)
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Gina M. DeNicola et al.
NATURE GENETICS (2015)
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
John T. Hinson et al.
SCIENCE (2015)
Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
Ioannis Karakikes et al.
NATURE COMMUNICATIONS (2015)
Neu-Laxova Syndrome Is a Heterogeneous Metabolic Disorder Caused by Defects in Enzymes of the L-Serine Biosynthesis Pathway
Rocio Acuna-Hidalgo et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2014)
Neu-Laxova Syndrome, an Inborn Error of Serine Metabolism, Is Caused by Mutations in PHGDH
Ranad Shaheen et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2014)
Go6976, a FLT3 kinase inhibitor, exerts potent cytotoxic activity against acute leukemia via inhibition of survivin and MCL-1
Akira Yoshida et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
Caroline A. Lewis et al.
MOLECULAR CELL (2014)
Poor Prognosis of Rare Sarcomeric Gene Variants in Patients with Dilated Cardiomyopathy
Marco Merlo et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2013)
Genetic mutations and mechanisms in dilated cardiomyopathy
Elizabeth M. McNally et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Cardiac Structural and Sarcomere Genes Associated With Cardiomyopathy Exhibit Marked Intolerance of Genetic Variation
Stephen Pan et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2012)
Resurgence of Serine: An Often Neglected but Indispensable Amino Acid
Satish C. Kalhan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
R222Q SCN5A Mutation Is Associated With Reversible Ventricular Ectopy and Dilated Cardiomyopathy
Stefan A. Mann et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
Jiangbin Ye et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A bioinformatic assay for pluripotency in human cells
Franz-Josef Mueller et al.
NATURE METHODS (2011)
Serine Biosynthesis with One Carbon Catabolism and the Glycine Cleavage System Represents a Novel Pathway for ATP Generation
Alexei Vazquez et al.
PLOS ONE (2011)
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
Fady I. Malik et al.
SCIENCE (2011)
TRB3 Function in Cardiac Endoplasmic Reticulum Stress
Joan Avery et al.
CIRCULATION RESEARCH (2010)
The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells
Chong Wee Liew et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Clinical and Functional Characterization of TNNT2 Mutations Identified in Patients With Dilated Cardiomyopathy
Ray E. Hershberger et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2009)
Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
Jin Seo et al.
DIABETES (2009)
Novel Mutations in 3-Phosphoglycerate Dehydrogenase (PHGDH) Are Distributed Throughout the Protein and Result in Altered Enzyme Kinetics
L. Tabatabaie et al.
HUMAN MUTATION (2009)
Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders
David M. Goldstein et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway
Celine Jousse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ARRY-797, a potent and selective inhibitor of p38 map kinase, inhibits LPS-induced IL-6 and in vivo growth of RPMI-8226 human multiple myeloma cells.
Dale Wright et al.
BLOOD (2006)
Go6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells
Victoria L. Grandage et al.
BRITISH JOURNAL OF HAEMATOLOGY (2006)
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
N Ohoka et al.
EMBO JOURNAL (2005)
Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy
J Mogensen et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
E Kiss-Toth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Gö 6976 Is a Potent Inhibitor of Neurotrophin-Receptor Intrinsic Tyrosine Kinase
M. Margarita Behrens et al.
JOURNAL OF NEUROCHEMISTRY (2003)
TRB3:: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
KY Du et al.
SCIENCE (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding et al.
MOLECULAR CELL (2003)
Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency -: A neurometabolic disorder associated with reduced L-serine biosynthesis
LWJ Klomp et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2000)
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
FV Lali et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
分享论文
