The expression and significance of vascular endothelial growth factor A in adenoid cystic carcinoma of palatal salivary gland

Objective To explore the VEGF-A expression in salivary gland adenoid cystic carcinoma tissues and detect the relationship between the mechanism of occurrence, development and metastasis of jaws with salivary gland adenoid cystic carcinoma and VEGF-A expression. Methods Paraffin samples from 58 cases of SACC of the palate and ten cases of normal salivary gland tissues were collected. The expression levels of VEGF-A protein were detected using the immunohistochemistry EnVision system. Results Among the 58 cases, there were 20 cases of the cribriform type, 17 cases of the tubular type, and 21 cases of the solid type. There were 9 cases with lymph node metastasis and 21 cases without lymph node metastasis. And there were 8 cases of T1, 15 cases of T2, and 7 cases of T3/T4. The positive expression rate of VEGF-A in SACC of the palate was 74.1%, which was higher than that found in normal salivary gland tissues (10%). The VEGF-A was localized in the cytoplasm/cell membrane. Conclusion VEGF-A is highly expressed in SACC of the palate. The level of expression is closely related to the pathological grade, lymph node metastasis, and clinical stage of the tumor, and it can thus be used as an important indicator for judging the biological behavior of SACC of the palate.

Automated summary

This study investigates the expression of VEGF-A in salivary gland adenoid cystic carcinoma tissues and explores its relationship with the occurrence, development, and metastasis of the tumor. The results show that VEGF-A is highly expressed in this type of cancer and its expression level is closely associated with the pathological grade, lymph node metastasis, and clinical stage of the tumor. VEGF-A can be used as an important indicator for judging the biological behavior of salivary gland adenoid cystic carcinoma.