期刊
EPIDEMIOLOGY
卷 33, 期 5, 页码 616-623出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/EDE.0000000000001515
关键词
Cohort; Phenol exposure; Bisphenol; Triclosan; Paraben; Pooled biospecimens; Fetal growth; Birth outcomes
资金
- French Research Agency [ANR-14-CE21-0007, ANR-15-IDEX-02]
- European Union [825712, 874583]
- European Research Council [311765-E-DOHaD]
- European Community [308333-892 HELIX]
- ANR [ANR-14-CE21-0007, ANR-12-PDOC-0029-01, ANR-18-CE36-005, ANR-19-CE36-0003-01]
- French Agency for Food, Environmental and Occupational Health Safety-ANSES [EST-2016-121, EST-2019/1/039]
- Plan Cancer (Canc'Air project)
- French Cancer Research Foundation Association de Recherche sur le Cancer-ARC
- French Endowment Fund AGIR for chronic diseases-APMC
- French Endowment Fund for Respiratory Health
- French FundFoundation de France [CLIMATHES-00081169, SEPAGES 5-00099903]
- Agence Nationale de la Recherche (ANR) [ANR-12-PDOC-0029, ANR-19-CE36-0003, ANR-14-CE21-0007] Funding Source: Agence Nationale de la Recherche (ANR)
This study found associations between prenatal exposure to phenols and fetal growth, with benzophenone-3 exposure being consistently positively associated with all growth parameters.
Background: Some synthetic phenols alter pathways involved in fetal development. Despite their high within-subject temporal variability, earlier studies relied on spot urine samples to assess pregnancy exposure. In this study, we examined associations between prenatal phenol exposure and fetal growth. Methods: We measured concentrations of two bisphenols, four parabens, benzophenone-3, and triclosan in 478 pregnant women in two weekly pools of 21 samples each, collected at 18 and 34 gestational weeks. We used adjusted linear regressions to study associations between phenol concentrations and growth outcomes assessed twice during pregnancy and at birth. Results: Benzophenone-3 was positively associated with all ultrasound growth parameters in at least one time point, in males but not females. In females, butylparaben was negatively associated with third-trimester abdominal circumference and weight at birth. We observed isolated associations for triclosan (negative) and for methylparaben and bisphenol S (positive) and late pregnancy fetal growth. Conclusions: Our results suggest associations between prenatal exposure to phenols and fetal growth. Benzophenone-3 was the exposure most consistently (positively) associated across all growth parameters.
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