期刊
ENVIRONMENTAL POLLUTION
卷 306, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2022.119360
关键词
Chlorella vulgaris; Androstenedione; Chlorophyll metabolism; Wastewaters
资金
- National Key Research and Devel-opment Program-China [2017YFE0122800]
- Shandong Provincial Nat-ural Science Foundation [ZR2019MC060]
- One Hundred Excellent Talents Support Program of Jining University [2020ZYRC10]
- Doctoral Scientific Research Foundation of Jining University [2019BSZX06]
- National Natural Science Foundation of China [51906219]
- Science and Technology Support Plan for Youth Innovation of Colleges and Univer-sities of Shandong Province [2021KJ109]
Through gene regulatory network analysis, it was found that chlorophyll plays a key role in the toxicological response of Chlorella to ADSD contamination, and a possible chlorophyll metabolism pathway was proposed.
Androstenedione (ADSD) was the main androgen detected in wastewaters. Chlorella was the most widely used plant in biological wastewater treatment process. In order to understand the toxicological response of chlorella to ADSD contamination, we used the weighted gene co-expression network analysis (WGCNA) method to systematically analyze the gene regulatory networks of chlorella after ADSD treatments. Total of 25 modules was identified from gene co-expression networks, and the turquoise module were selected for GO and KEGG enrichment analysis. Results showed that most hub genes were associated with chloroplast organizations or photosystems processes. Among them, the expressions profiles of hcar, nol, pao and sgr genes were highly correlated to the content fluctuations of chlorophylls after different ADSD treatments. All these results demonstrated that chlorophylls play a key role in preventing cell damage of chlorella caused by ADSD contamination. Besides, we proposed a possible chlorophyll metabolism pathway in chlorella response to ADSD contamination.
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