4.6 Review

Insights into the monkeypox virus: Making of another pandemic within the pandemic?

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Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022

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Summary: Since May 2022, there has been an ongoing monkeypox outbreak in non-endemic countries. Four cases in young adult men in Italy, who engaged in condomless sexual intercourse, were reported. The patients are in good clinical condition and do not require specific antiviral drugs. Monkeypox viral DNA was detected in seminal fluid samples. The possibility of sexual transmission of monkeypox virus needs to be investigated.

EUROSURVEILLANCE (2022)

Article Infectious Diseases

Clinical features and management of human monkeypox: a retrospective observational study in the UK

Hugh Adler et al.

Summary: This study retrospectively observed the clinical course of monkeypox in seven patients in the UK from 2018 to 2021. The study found that prolonged PCR positivity led to isolation of five patients for more than 3 weeks. Three patients treated with brincidofovir developed elevated liver enzymes, leading to termination of the therapy. One patient treated with tecovirimat experienced no adverse effects and had a shorter duration of viral shedding and illness compared to the other six patients.

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The 2022 outbreak and the pathobiology of the monkeypox virus

Narendra Kumar et al.

Summary: Two cases of monkeypox virus infection in individuals returning from Nigeria to the USA have led to a dramatic increase in infection rates. As of June 10, 2022, over 1,500 cases have been reported in 43 countries, including Europe and North America. While monkeypox virus is prevalent in central and western Africa, its presence in developed countries has raised concerns about global spread.

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Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

Joana Isidro et al.

Summary: In this study, shotgun metagenomics were used to rapidly reconstruct and characterize the genome sequences of the largest monkeypox virus outbreak in non-endemic countries so far. The findings indicate that the outbreak most likely has a single origin and that the virus belongs to clade 3. Furthermore, the study suggests the involvement of host APOBEC3 in viral evolution and reveals signs of ongoing microevolution in the virus.

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Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022

John P. Thornhill et al.

Summary: This report describes 528 cases of monkeypox in 16 countries. Common clinical findings include rash, mucosal lesions, fever, lethargy, and lymphadenopathy. Few patients required hospitalization.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Monkeypox: A Contemporary Review for Healthcare Professionals

Boghuma K. Titanji et al.

Summary: Monkeypox is an emerging zoonotic disease of global health concern that has significant epidemic potential. Healthcare professionals worldwide should familiarize themselves with the clinical presentations and management of this viral infection, especially in light of ongoing outbreaks.

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Illegal Wildlife Trade: A Gateway to Zoonotic Infectious Diseases

Marcos A. Bezerra-Santos et al.

Summary: The illegal wildlife trade poses serious threats to both human health and wildlife ecology, by spreading diseases and introducing exotic species.

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Imported Monkeypox, Singapore

Sarah Ee Fang Yong et al.

EMERGING INFECTIOUS DISEASES (2020)

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Human Monkeypox Epidemiologic and Clinical Characteristics, Diagnosis, and Prevention

Eskild Petersen et al.

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Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report

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Noam Erez et al.

EMERGING INFECTIOUS DISEASES (2019)

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Emerging/re-emerging viral diseases & new viruses on the Indian horizon

Devendra T. Mourya et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2019)

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Oral Tecovirimat for the Treatment of Smallpox

Douglas W. Grosenbach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Pharmacology & Pharmacy

Tecovirimat: First Global Approval

Sheridan M. Hoy

Article Infectious Diseases

Two cases of monkeypox imported to the United Kingdom, September 2018

Aisling Vaughan et al.

EUROSURVEILLANCE (2018)

Review Genetics & Heredity

The phylogenomics of evolving virus virulence

Jemma L. Geoghegan et al.

NATURE REVIEWS GENETICS (2018)

Review Public, Environmental & Occupational Health

Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans

Nikola Sklenovska et al.

FRONTIERS IN PUBLIC HEALTH (2018)

Article Immunology

Strengthening of Surveillance during Monkeypox Outbreak, Republic of the Congo, 2017

Reena H. Doshi et al.

EMERGING INFECTIOUS DISEASES (2018)

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Poxvirus Host Range Genes and Virus-Host Spectrum: A Critical Review

Graziele Pereira Oliveira et al.

VIRUSES-BASEL (2017)

Editorial Material Infectious Diseases

Emerging diseases-the monkeypox epidemic in the Democratic Republic of the Congo

A. Kantele et al.

CLINICAL MICROBIOLOGY AND INFECTION (2016)

Review Infectious Diseases

Human Monkeypox: Current State of Knowledge and Implications for the Future

Katy Brown et al.

TROPICAL MEDICINE AND INFECTIOUS DISEASE (2016)

Article Virology

A Phylogeographic Investigation of African Monkeypox

Yoshinori Nakazawa et al.

VIRUSES-BASEL (2015)

Review Infectious Diseases

What Factors Might Have Led to the Emergence of Ebola in West Africa?

Kathleen A. Alexander et al.

PLOS NEGLECTED TROPICAL DISEASES (2015)

Article Immunology

Human Monkeypox

Andrea M. McCollum et al.

CLINICAL INFECTIOUS DISEASES (2014)

Meeting Abstract Infectious Diseases

Ocular complications associated with acute monkeypox virus infection, DRC

C. Hughes et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2014)

Article Immunology

Genomic Variability of Monkeypox Virus among Humans, Democratic Republic of the Congo

Jeffrey R. Kugelman et al.

EMERGING INFECTIOUS DISEASES (2014)

Article Virology

Nipah virus infection: current scenario

D. D. Kulkarni et al.

INDIAN JOURNAL OF VIROLOGY (2013)

Article Public, Environmental & Occupational Health

The impact of declining vaccination coverage on measles control: a case study of Abia state Nigeria

Chukwuemeka Anthony Umeh et al.

PAN AFRICAN MEDICAL JOURNAL (2013)

Review Biochemistry & Molecular Biology

Outbreaks of human monkeypox after cessation of smallpox vaccination

Mary G. Reynolds et al.

TRENDS IN MICROBIOLOGY (2012)

Article Virology

Factors affecting the likelihood of monkeypox's emergence and spread in the post-smallpox era

Mary G. Reynolds et al.

CURRENT OPINION IN VIROLOGY (2012)

Article Public, Environmental & Occupational Health

A Silent Enzootic of an Orthopoxvirus in Ghana, West Africa: Evidence for Multi-Species Involvement in the Absence of Widespread Human Disease

Mary G. Reynolds et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2010)

Article Multidisciplinary Sciences

Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo

Anne W. Rimoin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Immunology

Human Monkeypox Outbreak Caused by Novel Virus Belonging to Congo Basin Clade, Sudan, 2005

Pierre Formenty et al.

EMERGING INFECTIOUS DISEASES (2010)

Article Biotechnology & Applied Microbiology

A prairie dog animal model of systemic orthopoxvirus disease using West African and Congo Basin strains of monkeypox virus

Christina L. Hutson et al.

JOURNAL OF GENERAL VIROLOGY (2009)

Article Immunology

Severe eczema vaccinatum in a household contact of a smallpox vaccinee

Surabhi Vora et al.

CLINICAL INFECTIOUS DISEASES (2008)

Article Microbiology

Human monkeypox: an emerging zoonotic disease

Scott Parker et al.

FUTURE MICROBIOLOGY (2007)

Review Microbiology

Poxvirus tropism

G McFadden

NATURE REVIEWS MICROBIOLOGY (2005)

Article Virology

Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox

JW Hooper et al.

JOURNAL OF VIROLOGY (2004)

Article Medicine, General & Internal

The detection of monkeypox in humans in the Western Hemisphere

KD Reed et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Review Infectious Diseases

Human monkeypox: an emerging zoonosis

DB Di Giulio et al.

LANCET INFECTIOUS DISEASES (2004)

Review Virology

Analysis of the monkeypox virus genome

SN Shchelkunov et al.

VIROLOGY (2002)