期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 480, 期 -, 页码 63-68出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2016.07.002
关键词
Prussian blue; Near infrared; Photothermal; Gram positive; Gram negative; Bacteria
资金
- Centre National de la Recherche Scientifique (CNRS)
- University Lille 1
- Nord-Pas-de Calais region
- Institut Universitaire de France (IUF)
- National Natural Science Foundation of China [51202019, 51402284]
- Twelfth Five Year Plan of The Education Department of Jilin Province for Science and Technology Study [2014-266]
A 980 nm laser-driven antimicrobial photothermal therapy using poly(vinylpyrrolidone)-coated Prussian Blue nanoparticles (PVP/PB NPs) is demonstrated. This approach allows an efficient eradication of a virulent strain of Gram-negative Escherichia coli (E. coli) associated with urinary tract infection as well as for the ablation of antibiotic resistant pathogens such as methicillin resistant Staphylococcus aureus (MRSA) and extended spectrum beta-lactamase (ESBL) E. coli. Interestingly the 980 nm irradiation exhibits minimal effect on mammalian cells up to a PVP/PB NPs concentration of 50 mu g mL(-1), while at this concentration bacteria are completely eradicated. This feature is certainly very promising for the selective targeting of bacteria over mammalian cells. (C) 2016 Elsevier Inc. All rights reserved.
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