4.5 Review

ERK1/2-RSK2 Signaling in Regulation of ERα-Mediated Responses

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

An oral first-in-class small molecule RSK inhibitor suppresses AR variants and tumor growth in prostate cancer

Miho Ushijima et al.

Summary: PMD-026, a novel ribosomal S6 kinase inhibitor, shows excellent antitumor effect in castration-resistant prostate cancer by regulating the YB-1/AR signaling pathway. PMD-026 alone or in combination with the antiandrogen drug enzalutamide inhibits cell proliferation, induces apoptosis, and G2/M arrest, effectively suppressing tumor growth.

CANCER SCIENCE (2022)

Review Biochemistry & Molecular Biology

MAPK-Activated Protein Kinases: Servant or Partner?

Natalia Ronkina et al.

Summary: Mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) are exclusively activated by MAPKs and play a role in regulating gene expression, RNA processing, and protein synthesis. They are promising targets for cancer therapy and treatments for conditions of inflammation.

ANNUAL REVIEW OF BIOCHEMISTRY (2022)

Article Oncology

Simultaneous Targeting of RSK and AKT Efficiently Inhibits YB-1-Mediated Repair of Ionizing Radiation-Induced DNA Double-Strand Breaks in Breast Cancer Cells

Konstanze Lettau et al.

Summary: The study demonstrates that simultaneous targeting of RSK and AKT can effectively inhibit the repair of DSBs in breast cancer cells after irradiation, leading to increased radiosensitization.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Review Oncology

MEK inhibitor resistance mechanisms and recent developments in combination trials

E. Kun et al.

Summary: The MAPK pathway is crucial in cancer development, and drugs targeting this pathway, especially MEK inhibitors, have shown promise. However, research and solutions regarding adaptive resistance mechanisms to MEK inhibitors are still challenging.

CANCER TREATMENT REVIEWS (2021)

Article Biochemistry & Molecular Biology

The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer

Theresa E. Hickey et al.

Summary: Studies have shown that androgen receptor (AR) plays a tumor suppressor role in estrogen receptor (ER)-positive breast cancer, with AR activation helping to suppress cell cycle genes and promote the expression of tumor suppressor genes, enhancing therapeutic responses.

NATURE MEDICINE (2021)

Article Developmental Biology

Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice

Ejimedo Madogwe et al.

Summary: This study demonstrates that sustained ERK1/2 signaling is crucial for follicular rupture during ovulation in mice, while it is not required for cumulus expansion, oocyte meiotic maturation and luteinization.

REPRODUCTION (2021)

Article Biology

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

Yongjian Huang et al.

Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Review Pharmacology & Pharmacy

G protein-coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex-specific manner?

Quynh Nhu Dinh et al.

Summary: Estrogen plays a crucial role in inhibiting cardiovascular disease development in women, but estrogen replacement therapy in postmenopausal women has varying effects on cardiovascular risk. Selective activation of GPER can effectively promote cardiovascular protection, with more significant benefits observed in ovariectomised females or males.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

Yichen Xu et al.

Summary: ERα plays a crucial role in breast cancer as a non-canonical RNA-binding protein, separate from its DNA-binding activity. Through controlling different steps of RNA metabolism, ERα mediates alternative splicing of XBP1 and translation of eIF4G2 and MCL1 mRNA, facilitating cell survival under stress conditions and maintaining tamoxifen resistance.
Article Multidisciplinary Sciences

Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer

Derek K. Cheng et al.

Summary: The study identified protein interactors of active KRAS in PDAC cells using proximity labeling, revealing that RSK1 selectively interacts with membrane-bound KRASG12D through NF1 and SPRED2. It was found that membrane RSK1 mediates negative feedback on WT RAS signaling and impedes the proliferation of pancreatic cancer cells upon the ablation of mutant KRAS in PDAC, highlighting the role of WT RAS signaling in promoting adaptive resistance to mutant KRAS-specific inhibitors.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Medicine, General & Internal

Menopausal hormone therapy and women's health: An umbrella review

Guo-Qiang Zhang et al.

Summary: The study comprehensively summarized 60 systematic reviews on the use of menopausal hormone therapy in women, revealing a complex balance of benefits and harms across multiple health outcomes. The findings suggest potential health risks associated with MHT, highlighting the importance of further research in this area.

PLOS MEDICINE (2021)

Article Oncology

A Novel Protein-Protein Interaction between RSK3 and IκBα and a New Binding Inhibitor That Suppresses Breast Cancer Tumorigenesis

Hee-Sub Yoon et al.

Summary: This study identified a new PPI inhibitor and revealed the role of RSK3 in cancer cell viability. Phosphorylation of I kappa B alpha by active RSK3 kinase affects breast tumorigenesis. The RSK3/I kappa B alpha-specific binding inhibitor shows potential as a lead compound for new anticancer drugs.

CANCERS (2021)

Review Biochemistry & Molecular Biology

RASopathies: From germline mutations to somatic and multigenic diseases

Quentin Riller et al.

Summary: The RAS-RAF-MEK-ERK signaling pathway plays a critical role in cellular mechanisms, with mutations in this pathway associated with cancer, RASopathies, and rare disorders.

BIOMEDICAL JOURNAL (2021)

Article Biochemistry & Molecular Biology

Identifying requirements for RSK2 specific inhibitors

Eric B. Wright et al.

Summary: The study identified a natural product, SL0101, that binds specifically to RSK1/2 by inducing conformational rearrangement, but not to RSK3/4 due to a single amino acid difference. Kinetic analysis revealed that regions outside of the N-terminal kinase domain also contribute to stable inhibitor binding towards RSK2. Additionally, a modification on SL0101 was discovered to form a highly stable inhibitor complex with RSK2, suggesting potential for identifying RSK2-specific inhibitors.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

Review Oncology

The plasticity of mRNA translation during cancer progression and therapy resistance

Lucilla Fabbri et al.

Summary: Translational control of mRNAs during gene expression allows rapid and specific changes in the cell proteome, promoting cancer onset, progression, and resistance to anticancer therapies. This mechanism enables cells to promptly adapt to stimuli from oncogenic signaling and microenvironmental stress, shaping specific cancer phenotypes.

NATURE REVIEWS CANCER (2021)

Review Oncology

The MEK/ERK Network as a Therapeutic Target in Human Cancer

Renee Barbosa et al.

Summary: The RAS-RAF-MEK-ERK pathway is crucial for cell proliferation, differentiation, and survival, with mutations in upstream proteins RAS and RAF contributing to many human cancers and nearly all cutaneous melanomas. Targeting terminal kinases in the MAPK cascade has shown promise in overcoming drug resistance and improving treatment options for patients with MAPK-aberrant cancers.

MOLECULAR CANCER RESEARCH (2021)

Article Medicine, Research & Experimental

Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer

Lidia Moyano-Galceran et al.

EMBO MOLECULAR MEDICINE (2020)

Review Cell Biology

ERK signalling: a master regulator of cell behaviour, life and fate

Hugo Lavoie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Neurosciences

Oestradiol as a neuromodulator of learning and memory

Lisa R. Taxier et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Review Oncology

Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor

Rahul Mal et al.

FRONTIERS IN ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Targeting ERK beyond the boundaries of the kinase active site in melanoma

Rachel M. Sammons et al.

MOLECULAR CARCINOGENESIS (2019)

Review Biochemistry & Molecular Biology

Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression

Nathan Lu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

Rapid estrogen receptor-alpha signaling mediated by ERK activation regulates vascular tone in male and ovary-intact female mice

Seong Chul Kim et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Review Medicine, Research & Experimental

Estrogen: The necessary evil for human health, and ways to tame it

Seema Patel et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Endocrinology & Metabolism

Estrogen Receptors: New Directions in the New Millennium

Sylvia C. Hewitt et al.

ENDOCRINE REVIEWS (2018)

Article Cell Biology

YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling

Padmanaban S. Suresh et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2018)

Article Oncology

High nuclear MSK1 is associated with longer survival in breast cancer patients

Xuan Pu et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Signaling Pathways Involved in the Regulation of mRNA Translation

Philippe P. Roux et al.

MOLECULAR AND CELLULAR BIOLOGY (2018)

Review Oncology

Defining the role of the RSK isoforms in cancer

Thibault Houles et al.

SEMINARS IN CANCER BIOLOGY (2018)

Review Behavioral Sciences

Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction

Matthias Fischer et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2018)

Article Cell & Tissue Engineering

Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38 alpha

Ivan del Barco Barrantes et al.

STEM CELL REPORTS (2018)

Article Endocrinology & Metabolism

High prevalence of syndromic disorders in patients with non-isolated central precocious puberty

Selmen Wannes et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Sex- and Age-Specific Impact of ERK Loss Within the Pituitary Gonadotrope in Mice

Jessica L. Brown et al.

ENDOCRINOLOGY (2018)

Article Medicine, Research & Experimental

Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors

Stergios J. Moschos et al.

JCI INSIGHT (2018)

Review Biochemistry & Molecular Biology

A compendium of ERK targets

Evrim B. Uenal et al.

FEBS LETTERS (2017)

Article Genetics & Heredity

Divergent effects of intrinsically active MEK variants on developmental Ras signaling

Yogesh Goyal et al.

NATURE GENETICS (2017)

Review Multidisciplinary Sciences

Mouse models to evaluate the role of estrogen receptor in skeletal maintenance and adaptation

Amanda M. Rooney et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Article Biochemistry & Molecular Biology

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

Daniel M. Freed et al.

Article Cell Biology

Feedback activation of neurofibromin terminates growth factor-induced Ras activation

Anne Hennig et al.

CELL COMMUNICATION AND SIGNALING (2016)

Review Biochemistry & Molecular Biology

Negative feedback regulation of the ERK1/2 MAPK pathway

David Lake et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Chemistry, Medicinal

Ribosomal S6 kinase (RSK) modulators: a patent review

Katarzyna A. Ludwik et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

Article Oncology

Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

Katarzyna A. Ludwik et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Review Oncology

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road

Christopher J. Caunt et al.

NATURE REVIEWS CANCER (2015)

Article Endocrinology & Metabolism

17β-Estradiol Replacement Reverses Age-Related Lung Disease in Estrogen-Deficient C57BL/6J Mice

Marilyn K. Glassberg et al.

ENDOCRINOLOGY (2014)

Article Multidisciplinary Sciences

RSK2 Is a Modulator of Craniofacial Development

Virginie Laugel-Haushalter et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Phosphorylation releases constraints to domain motion in ERK2

Yao Xiao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway

Yue-Hua Yang et al.

APOPTOSIS (2013)

Review Biochemistry & Molecular Biology

The role of estrogen receptor α in the regulation of bone and growth plate cartilage

A. E. Borjesson et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Medicine, Research & Experimental

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

Violeta Serra et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemistry & Molecular Biology

Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility

Xiaocui Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

Madhurima Saha et al.

BIOCHEMICAL JOURNAL (2012)

Review Microbiology

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

Marie Cargnello et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)

Article Multidisciplinary Sciences

MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility

Heng-Yu Fan et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival

T. S. Karin Eisinger-Mathason et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

Myungjin Kim et al.

EMBO JOURNAL (2006)

Article Cell Biology

p90Rsk is not involved in cytostatic factor arrest in mouse oocytes

J Dumont et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation

GL Razidlo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

MK Saba-El-Leil et al.

EMBO REPORTS (2003)

Article Biochemistry & Molecular Biology

Rsk2 allosterically activates estrogen receptor α by docking to the hormone-binding domain

DE Clarkl et al.

EMBO JOURNAL (2001)