New Insights on Effects of Glucocorticoids in Patients With SARS-CoV-2 Infection

Letter Respiratory System

High-dose versus low-dose prednisolone in symptomatic patients with post-COVID-19 diffuse parenchymal lung abnormalities: an open-label, randomised trial (the COLDSTER trial)

Sahajal Dhooria et al.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Letter Virology

Elevated interleukin-6 is associated with severity of COVID-19: A meta-analysis

Jieyun Zhu et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Endocrinology & Metabolism

Glucocorticoid excess and COVID-19 disease

Valentina Guarnotta et al.

Summary: Patients with hypercortisolism are at higher risk of developing severe COVID-19 infection due to increased susceptibility caused by glucocorticoid excess. The European Society of Endocrinology has recently issued urgent clinical guidance for managing Cushing's syndrome during the COVID-19 pandemic.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2021)

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Article Endocrinology & Metabolism

COVID-19 in Cushing disease: experience of a single tertiary centre in Lombardy

A. L. Serban et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

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Editorial Material Medicine, General & Internal

WHO recommends corticosteroids for patients with severe or critical COVID-19

Holly Keyt

ANNALS OF INTERNAL MEDICINE (2021)

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Article Endocrinology & Metabolism

The Impact of COVID-19 Viral Infection on the Hypothalamic-Pituitary-Adrenal Axis

Ali S. Alzahrani et al.

Summary: This study aimed to investigate the adrenocortical response to COVID-19 infection. The results revealed that patients with more severe disease had lower cortisol and ACTH levels, indicating a direct link between COVID-19 infection and impaired glucocorticoid response.

ENDOCRINE PRACTICE (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Daniel Wendisch et al.

Summary: Analysis of pulmonary immune responses and lung pathology in patients with COVID-19 ARDS revealed an accumulation of profibrotic macrophages and similarities with macrophage populations in idiopathic pulmonary fibrosis. Exposure to SARS-CoV-2 induced a profibrotic phenotype in human monocytes, suggesting a mechanistic link between the virus and fibroproliferative ARDS.

CELL (2021)

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Article Medicine, General & Internal

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

Carlos Salama et al.

Summary: Among hospitalized patients with Covid-19 pneumonia not on mechanical ventilation, tocilizumab reduced the risk of progression to mechanical ventilation or death, but did not improve overall survival. There were no new safety concerns identified.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Dysregulation of Cell Signaling by SARS-CoV-2

Rahul K. Suryawanshi et al.

Summary: SARS-CoV-2 infection manipulates host pathways, reorganizes host cell structure, impairs innate cellular defenses, and induces delayed hyperinflammation while weakening interferon response. Understanding the complex interactions between SARS-CoV-2 and host signaling pathways provides crucial strategic clues for the development of novel therapeutics.

TRENDS IN MICROBIOLOGY (2021)

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Letter Immunology

Role of Cell Adhesion Molecules for Prognosis of Disease Development of Patients With and Without COVID-19 in the Emergency Department

Wolfgang Bauer et al.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Editorial Material Medicine, General & Internal

Interleukin-6 Receptor Inhibition in Covid-19-Cooling the Inflammatory Soup

Eric J. Rubin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Methylprednisolone in adults hospitalized with COVID-19 pneumonia An open-label randomized trial (GLUCOCOVID)

Luis Corral-Gudino et al.

Summary: This study aimed to investigate whether methylprednisolone improves outcomes in severe COVID-19 patients. Results showed that patients on methylprednisolone had a significantly lower risk of experiencing the composite endpoint in the per protocol analysis. However, the planned sample size was not achieved, cautioning interpretation of the results.

WIENER KLINISCHE WOCHENSCHRIFT (2021)

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Review Cell Biology

The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases

Jae-Won Lee et al.

Summary: Macrophages play a crucial role in the development of inflammatory lung diseases by secreting inflammatory cytokines and chemokines to promote the progression of acute or chronic inflammatory responses.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels?

Tomoshige Kino et al.

Summary: The novel coronavirus disease COVID-19 has had a significant impact on human society, with the glucocorticoid dexamethasone identified as an effective treatment. Researchers suggest that SARS-CoV-2 infection may result in infected cell-specific glucocorticoid insensitivity, which makes dexamethasone effective for COVID-19 but harmful for other infectious diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

Patricia O. Guimaraes et al.

Summary: Among patients hospitalized with Covid-19 pneumonia, tofacitinib led to a lower risk of death or respiratory failure through day 28 than placebo. The mortality rate was lower in the tofacitinib group within 28 days. However, the rate of serious adverse events was similar in both groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Immunology

Elevated Serum Levels of Progranulin and Soluble Vascular Cell Adhesion Molecule-1 in Patients with COVID-19

Shifei Yao et al.

Summary: Elevated serum PGRN and sVCAM-1 levels were found in patients with COVID-19, potentially providing insights into the pathogenesis of COVID-19. After successful treatment, serum PGRN and sVCAM-1 levels in COVID-19 patients significantly decreased.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Respiratory System

The efficacy of corticosteroids therapy in patients with moderate to severe SARS-CoV-2 infection: a multicenter, randomized, open-label trial

Mostafa Ghanei et al.

Summary: The study showed that the low-dose prednisolone regimen was superior to other treatments in shortening the hospital stay of patients with moderate to severe COVID-19. The steroid-sparing effect may be beneficial in enhancing the effectiveness of corticosteroids for diabetic patients by reducing the dosage.

RESPIRATORY RESEARCH (2021)

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Article Endocrinology & Metabolism

Clinical course and outcome of patients with ACTH-dependent Cushing's syndrome infected with novel coronavirus disease-19 (COVID-19): case presentations

Zhanna Belaya et al.

Summary: In patients with endogenous Cushing's syndrome affected by COVID-19, the severity of hypercortisolism is a key factor in determining outcomes, with severe cases possibly requiring emergency care despite lack of clinical presentations and low inflammation biomarkers. One patient died due to severe hypercortisolism, while the other two recovered well. Mild cases of Cushing's disease remained asymptomatic even after infection with COVID-19.

ENDOCRINE (2021)

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Article Biochemistry & Molecular Biology

Clinical evidence of an interferon-glucocorticoid therapeutic synergy in COVID-19

Yingying Lu et al.

Summary: This study found that early interferon therapy in patients with COVID-19 who were also receiving glucocorticoids was associated with earlier hospital discharge, symptom relief, and lower prevalence of prolonged viral shedding. These associations were more significant in glucocorticoid users, indicating a potential therapeutic synergy between interferons and glucocorticoids in COVID-19.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology

The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients

Apurva Hariharan et al.

Summary: COVID-19 causes a cytokine storm mainly affecting the lungs, with elderly and patients with metabolic syndrome being more susceptible. Immunomodulation targeting NF-kappa B activation and inhibitors can potentially reduce the cytokine storm, alleviating the severity of COVID-19. Inhibition of the NF-kappa B pathway may play a therapeutic role in alleviating severe forms of COVID-19.

INFLAMMOPHARMACOLOGY (2021)

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Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Medicine, Research & Experimental

Immunopathogenesis and treatment of cytokine storm in COVID-19

Jae Seok Kim et al.

Summary: Severe COVID-19 is characterized by systemic hyper-inflammation and cytokine storm, often leading to acute respiratory distress syndrome and multiple organ failure. Treatment of COVID-19 cytokine storm is crucial, with anti-inflammatory therapies playing a significant role. Various approaches are being used, including new cytokine-targeted therapies, to address the cytokine storm associated with COVID-19.

THERANOSTICS (2021)

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Article Medicine, General & Internal

New onset adrenal insufficiency in a patient with COVID-19

Maram Hashim et al.

Summary: SARS-CoV-2, the virus causing COVID-19, can lead to adrenal insufficiency in patients. Early diagnosis and treatment are crucial for improving patient outcomes.

BMJ CASE REPORTS (2021)

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Article Critical Care Medicine

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Xiaobo Yang et al.

Lancet Respiratory Medicine (2020)

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Article Critical Care Medicine

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials

Pratik Sinha et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Allergy

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

Tobias Herold et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Endocrinology & Metabolism

Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery

Alessandro Prete et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

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Letter Virology

Elevated interleukin-6 and severe COVID-19: A meta-analysis

Muhammad Aziz et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Review Endocrinology & Metabolism

The Immune System in Cushing's Syndrome

Valeria Hasenmajer et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

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Review Immunology

Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine

Silvia Capellino et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Letter Endocrinology & Metabolism

Association between high serum total cortisol concentrations and mortality from COVID-19

Tricia Tan et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

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Article Medicine, General & Internal

Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19 A Randomized Clinical Trial

Pierre-Francois Dequin et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis

Jonathan A. C. Sterne et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Endocrinology & Metabolism

Practical Considerations for the Management of Cushing's Disease and COVID-19: A Case Report

Federica Beretta et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Critical Care Medicine

Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes

Judith van Paassen et al.

CRITICAL CARE (2020)

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Review Rheumatology

Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment

Stuart J. Carter et al.

RHEUMATOLOGY (2019)

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Review Biochemistry & Molecular Biology

Context-Dependent Effect of Glucocorticoids on the Proliferation, Differentiation, and Apoptosis of Regulatory T Cells: A Review of the Empirical Evidence and Clinical Applications

Luigi Cari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Immunology

Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses

Luis M. Franco et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Review Immunology

Glucocorticoids Shape Macrophage Phenotype for Tissue Repair

Thibaut Desgeorges et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Annexin-A1: Therapeutic Potential in Microvascular Disease

Gareth S. D. Purvis et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages

Jan M. Ehrchen et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Critical Care Medicine

Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017

Stephen M. Pastores et al.

CRITICAL CARE MEDICINE (2018)

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Article Respiratory System

The relationship between high-dose corticosteroid treatment and mortality in acute respiratory distress syndrome: a retrospective and observational study using a nationwide administrative database in Japan

Takashi Kido et al.

BMC PULMONARY MEDICINE (2018)

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Article Critical Care Medicine

The negative effect of initial high-dose methylprednisolone and tapering regimen for acute respiratory distress syndrome: a retrospective propensity matched cohort study

Makoto Takaki et al.

CRITICAL CARE (2017)

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Review Biochemistry & Molecular Biology

A gradient of glucocorticoid sensitivity among helper T cell cytokines

Jesus Banuelos et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

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Article Endocrinology & Metabolism

One Hormone, Two Actions: Anti- and Pro-Inflammatory Effects of Glucocorticoids

Diana Cruz-Topete et al.

NEUROIMMUNOMODULATION (2015)

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Article Cell Biology

Glucocorticoids regulate natural killer cell function epigenetically

Justin L. Eddy et al.

CELLULAR IMMUNOLOGY (2014)

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Review Endocrinology & Metabolism

New Insights into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for Glucocorticoid-Receptor-Mediated Transactivation

Sofie Vandevyver et al.

ENDOCRINOLOGY (2013)

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Article Medicine, General & Internal

Reduced Cortisol Metabolism during Critical Illness

Eva Boonen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Proceedings Paper Endocrinology & Metabolism

Exploring the Molecular Mechanisms of Glucocorticoid Receptor Action from Sensitivity to Resistance

Sivapriya Ramamoorthy et al.

HORMONE RESISTANCE AND HYPERSENSITIVITY: FROM GENETICS TO CLINICAL MANAGEMENT (2013)

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Article Immunology

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

Marni N. Silverman et al.

NEUROIMMUNOMODULATION IN HEALTH AND DISEASE I (2012)

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Review Cell Biology

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

Agnes E. Coutinho et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

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Review Biochemistry & Molecular Biology

Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function

Istvan Szatmari et al.

EMBO JOURNAL (2008)

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Article Pharmacology & Pharmacy

Endogenous glucocorticoids control neutrophil mobilization from bone marrow to blood and tissues in non-inflammatory conditions

D. M. H. Cavalcanti et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

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Article Immunology

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

Hee-Young Lim et al.

IMMUNOLOGY (2007)

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Article Hematology

Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes

Jan Ehrchen et al.

BLOOD (2007)

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Article Endocrinology & Metabolism

Cortisol response in relation to the severity of stress and illness

IE Widmer et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

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Article Neurosciences

Rapid non-genomic inhibition of ATP-induced Cl- secretion by dexamethasone in human bronchial epithelium

V Urbach et al.

JOURNAL OF PHYSIOLOGY-LONDON (2002)

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Article Medicine, General & Internal

Dexamethasone in adults with bacterial meningitis.

J de Gans et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Article Rheumatology

Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens:: current questions and tentative answers in rheumatology

F Buttgereit et al.

ANNALS OF THE RHEUMATIC DISEASES (2002)

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Article Allergy

Glucocorticoids induce basophil apoptosis

C Yoshimura et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2001)

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Article Medicine, General & Internal

Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment

C Henzen et al.

LANCET (2000)

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New Insights on Effects of Glucocorticoids in Patients With SARS-CoV-2 Infection

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