Metastatic Risk Stratification of 2526 Medullary Thyroid Carcinoma Patients: A Study Based on Surveillance, Epidemiology, and End Results Database

Article Oncology

International Medullary Thyroid Carcinoma Grading System: A Validated Grading System for Medullary Thyroid Carcinoma

Bin Xu et al.

Summary: This study aimed to establish an internationally recognized grading system for medullary thyroid carcinoma (MTC) to predict adverse outcomes by evaluating mitotic activity, Ki67 proliferative index, and tumor necrosis in MTC.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Surgery

Association between age and disease specific mortality in medullary thyroid cancer

Zeyad T. Sahli et al.

Summary: The study evaluated the association between age and disease specific mortality among adults diagnosed with medullary thyroid cancer. Older adults and super-elderly were found to have a higher risk of increased mortality, with age being an independent predictor of disease specific mortality. The extent of surgery and lymphadenectomy did not affect disease specific mortality in these patients.

AMERICAN JOURNAL OF SURGERY (2021)

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Article Oncology

Construction and Validation of a Nomogram Based on the Log Odds of Positive Lymph Nodes to Predict the Prognosis of Medullary Thyroid Carcinoma After Surgery

Jiajia Tang et al.

Summary: LODDS is an independent prognostic factor for MTC, showing superior prognostic efficiency over N status and PLNN, and its prediction model performs better than the AJCC TNM system in predicting CSS for MTC after surgery.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Article Endocrinology & Metabolism

Predicting Outcomes in Sporadic and Hereditary Medullary Thyroid Carcinoma over Two Decades

Anupam Kotwal et al.

Summary: The study identified disease burden at initial surgery and biochemical response to surgery as important predictors of overall survival, disease-specific survival, locoregional recurrence/persistence, and distant metastases in patients with medullary thyroid cancer. Demographic factors were found to be less significant in predicting prognosis.

THYROID (2021)

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Review Endocrinology & Metabolism

Current Guidelines for Management of Medullary Thyroid Carcinoma

Mijin Kim et al.

Summary: Recent guidelines for the management of sporadic medullary thyroid carcinoma have shown advances in individualized treatment, multi-kinase inhibitors, and potent selective RET inhibitors, offering promising efficacy in clinical trials.

ENDOCRINOLOGY AND METABOLISM (2021)

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Article Multidisciplinary Sciences