期刊
DYSPHAGIA
卷 38, 期 3, 页码 731-743出版社
SPRINGER
DOI: 10.1007/s00455-022-10508-3
关键词
Lung allograft injury; Lung transplantation; Dysphagia; Esophageal reflux
Esophageal dysfunction following lung transplant, such as gastroesophageal reflux and esophageal hypercontractility, plays a significant role in lung injury, especially in chronic cases. Its impact in acute lung injury is still being studied.
The prevalence of lung transplants has increased over the years, albeit with a low survival rate amongst all solid organ transplants, including liver and heart transplantation. Microaspiration is one of the primary mechanisms that has been implicated in the pathogenesis of lung injury following lung transplants. Of late, esophageal dysfunction such as gastroesophageal reflux and esophageal hypercontractility is often noted post-lung transplant. However, reflux is associated with chronic allograft lung injury such as bronchiolitis obliterans syndrome, which is one of the predictors for long-term survival in this specialized population. Its role in acute lung injury post-lung transplant is still being explored. This review critically examines the salient points which provide the current understanding of the characteristics, pathophysiology, and implications of esophageal dysfunction following lung transplant.
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