Pyroptosis in host defence against bacterial infection

Article Multidisciplinary Sciences

Bacterial gasdermins reveal an ancient mechanism of cell death

Alex G. Johnson et al.

Summary: Gasdermin proteins play important roles in immune regulation and induction of cell death in human cells by forming membrane pores. Similar proteins encoded by bacteria have been found to defend against phages and execute cell death.

SCIENCE (2022)

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Editorial Material Cell Biology

ADP-riboxanation: a new pyroptosis evasion strategy

Heyu Li et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2022)

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Article Immunology

Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages

Anna M. Gram et al.

Summary: The study demonstrates that flagellin from S. Typhimurium can induce cell death and cytokine secretion, with NLRP3 and NAIP/NLRC4 playing redundant roles in inflammasome activation during infection.

JOURNAL OF IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

NINJ1 mediates plasma membrane rupture during lytic cell death

Nobuhiko Kayagaki et al.

Summary: Plasma membrane rupture is a cataclysmic event in lytic cell death, releasing damage-associated molecular patterns to propagate the inflammatory response. NINJ1 protein plays an essential role in inducing PMR, with Ninj1-deficient macrophages showing impaired release of intracellular proteins and distinctive ballooned morphology. This study overturns the long-held belief that cell death-related PMR is a passive event, highlighting the active role of NINJ1 in mediating PMR.

NATURE (2021)

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Review Microbiology

Shigella infection and host cell death: a double-edged sword for the host and pathogen survival

Hiroshi Ashida et al.

Summary: In response to bacterial infection, epithelial cells undergo various types of cell death, while Shigella maintains its foothold in the intestinal epithelium by delivering effector proteins to prevent host cell death and facilitate replication. Shigella's evasion of host cell death pathways demonstrates bacterial fine-tuning of infection strategies.

CURRENT OPINION IN MICROBIOLOGY (2021)

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Review Immunology

Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection

Kristin L. Patrick et al.

Summary: Mitochondria can activate innate immune pathways evolved to sense and respond to intracellular pathogens during infection. While similarities exist between how cells respond to bacterial and mitochondrial ligands, the potential for cross talk or synergy between bacterium- and mitochondrion-driven innate immune responses remains poorly understood.

INFECTION AND IMMUNITY (2021)

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Article Multidisciplinary Sciences

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

Zilin Li et al.

Summary: This study identified a novel post-translational modification, ADP riboxanation, mediated by the Shigella effector OspC3, which inactivates the LPS sensing pathway of caspase-4 and caspase-11 and prevents pyroptosis. ADP riboxanation modification on Arg314 and Arg310 in caspase-4 and caspase-11 inhibits their activity, leading to evasion of host defense against Shigella infection. This bacterial virulence mechanism highlights the importance of ADP riboxanation in preventing LPS-induced pyroptosis.

NATURE (2021)

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Article Immunology

Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish

Weijie Chen et al.

Summary: The study revealed the involvement of the pyroptotic signaling in the formation of neutrophil extracellular traps (NET), which is crucial for teleost innate immunity.

JOURNAL OF IMMUNOLOGY (2021)

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Review Multidisciplinary Sciences

Dying cells fan the flames of inflammation

Kim Newton et al.

Summary: Inflammatory processes are crucial for tissue repair and pathogen elimination, but excessive or chronic inflammation can lead to diseases such as arthritis and COVID-19. Different cell death mechanisms like apoptosis, necroptosis, and pyroptosis may contribute to inflammatory diseases. Inhibiting cell death and targeting specific mediators of lytic cell death could be potential therapeutic strategies.

SCIENCE (2021)

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Review Multidisciplinary Sciences

Emerging technologies and infection models in cellular microbiology

Ana Teresa Lopez-Jimenez et al.

Summary: Cellular microbiology, a field that studies intracellular pathogens and their manipulation of host cells, has seen recent advances in technologies and infection models that are driving the development of new strategies for combating infections and improving human health. A focus on microscopy, robotics, artificial intelligence, and advanced imaging techniques has led to a deeper understanding of the host-pathogen interface and the infection process within cells, offering promising opportunities for future medical advancements.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Hyperinflammatory Immune Response and COVID-19: A Double Edged Sword

Li Yin Tan et al.

Summary: COVID-19 caused by SARS-CoV-2 can lead to severe health consequences, including acute respiratory distress syndrome and multi-organ failure, through activation of inflammatory pathways and cytokine storm. Long-term effects, particularly on the brain, are of concern.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

Stefan A. Fattinger et al.

Summary: The gut epithelium serves as a critical barrier against infection by Gram-negative bacteria, with the NAIP/NLRC4 inflammasome playing a key role in sensing and responding to such infections. In NAIP/NLRC4-deficient mice, severe enteropathy and epithelial barrier breakdown were observed, while hosts with functional NAIP/NLRC4 were able to control bacterial loads through a heterogeneous enterocyte death response, preventing excessive inflammatory reactions. These findings highlight the importance of the NAIP/NLRC4 inflammasome in maintaining gut homeostasis during bacterial infections.

MUCOSAL IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Gasdermin D pore structure reveals preferential release of mature interleukin-1

Shiyu Xia et al.

Summary: Inflammasomes activate caspase-1 to cleave GSDMD and generate mature cytokines like IL-1 beta and IL-18, which are released through pores formed by GSDMD. The GSDMD pore mediates IL-1 release by electrostatic filtering, favoring the passage of mature cytokines over their precursors.

NATURE (2021)

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Review Microbiology

Salmonella Typhimurium and inflammation: a pathogen-centric affair

Jorge E. Galan

Summary: Microbial infections are controlled by host inflammatory responses initiated by innate immune receptors recognizing microbial products. The enteric pathogen Salmonella Typhimurium triggers inflammation in the intestinal tract using effector proteins without engaging innate immune receptors, while also employing other effectors to restrict the inflammatory response and preserve host homeostasis. The interaction between S. Typhimurium and its host represents a unique balance achieved through co-evolution, with mechanisms aimed at recovering host homeostasis after the inflammatory response.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Cell Biology

Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense

Puja Kumari et al.

Summary: The study reveals that macrophage/monocyte-specific caspase-11 plays a dominant role in mediating the pathological manifestations of endotoxemia, while caspase-11 expression in neutrophils is dispensable for LPS-induced lethality. Sensing of intracellular LPS by LyzM(+) myeloid cells and MRP8(+) neutrophils is necessary for bacterial clearance and host survival during intracellular bacterial infection.

CELL REPORTS (2021)

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Article Microbiology

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

Giovanni Luchetti et al.

Summary: The study reveals the mechanism by which IpaH7.8 from Shigella ubiquitinates human GSDMD and targets it for proteasomal degradation, contributing to the bacterium's impact on humans rather than mice.

CELL HOST & MICROBE (2021)

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Article Multidisciplinary Sciences

Microbiota-derived metabolites inhibit Salmonella virulent subpopulation development by acting on single-cell behaviors

Alyson M. Hockenberry et al.

Summary: This study combines multiple methods to investigate the impact of short-chain fatty acids on Salmonella T3SS-1 gene expression, revealing that these compounds selectively slow the growth of T3SS-1-expressing cells, ultimately affecting their frequency in the population.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Mechanistic insight into bacterial entrapment by septin cage reconstitution

Damian Lobato-Marquez et al.

Summary: Septins are cytoskeletal proteins that form cage-like structures to restrict the movement of bacteria within cells. Research shows that septin complexes can recognize bacterial cells and assemble as filaments on their surface.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

Zsofi Digby et al.

Summary: The immune pathways in Carnivora have progressively evolved downregulation, potentially leading to certain pathogens residing undetected in the host.

CELL REPORTS (2021)

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Article Microbiology

Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF

Shivangi Rastogi et al.

Summary: The study reveals that Mtb manipulates host cell functions to interfere with host innate immunity, particularly inhibiting inflammasome activation. PknF protein in Mtb plays a crucial role in inhibiting the NLRP3 inflammasome.

PLOS PATHOGENS (2021)

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Letter Cell Biology

Pyroptosis is involved in ovulation of zebrafish

Zhiquan Liu et al.

CELL DISCOVERY (2021)

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Article Immunology

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β-converting enzyme

Pascal Devant et al.

Summary: Innate immune signaling pathways involve multiple proteins that promote inflammation, with the complexity being a prerequisite for pathway design. Through studying caspases that regulate inflammation, it was found that different caspases can complement each other, condensing a multistep pathway into a single protein.

SCIENCE IMMUNOLOGY (2021)

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Review Cell Biology

Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells

Jatuporn Ngoenkam et al.

Summary: The research focuses on the role of WASp-deficient T cells in TCR-mediated signal transduction. WASp plays a critical role in TCR signaling and is involved in pathways such as Ras/Rac-MAPK, PKC, and Ca2+ signaling.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Immunology

Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death

Li Zhang et al.

Summary: Research findings indicate that macrophage-derived type I interferons play a crucial role in the death of Mtb-infected macrophages in vitro, and blocking this signaling pathway may enhance the efficacy of TB drugs like rifampin. Further defining the pathway of type I interferon-mediated macrophage death may lead to more selective host-directed therapy for tuberculosis.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Correction Microbiology

Effector-triggered immunity and pathogen sensing in metazoans (vol 77, pg 1254, 2019)

Natasha Lopes Fischer et al.

NATURE MICROBIOLOGY (2020)

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Article Multidisciplinary Sciences

Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages

Sathyavani Subbarao et al.

SCIENTIFIC REPORTS (2020)

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Review Cell Biology

The history of septin biology and bacterial infection

Stevens Robertin et al.

CELLULAR MICROBIOLOGY (2020)

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Article Microbiology

Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus

Sebastien Lhomme et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Immunology

Manipulation of the Innate Immune Response by Varicella Zoster Virus

Chelsea Gerada et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Editorial Material Biochemistry & Molecular Biology

Shigella sonnei

Vincenzo Torraca et al.

TRENDS IN MICROBIOLOGY (2020)

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Article Multidisciplinary Sciences

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Kai S. Beckwith et al.

NATURE COMMUNICATIONS (2020)

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Article Microbiology

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes

Shauna M. Crowley et al.

PLoS Pathogens (2020)

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Article Biochemistry & Molecular Biology

Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions

Miriam Kutsch et al.

EMBO JOURNAL (2020)

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Article Immunology

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms

Michal P. Wandel et al.

NATURE IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Jose Carlos Santos et al.

NATURE COMMUNICATIONS (2020)

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Article Immunology

Hyperexpression of type III secretion system of Salmonella Typhi linked to a higher cytotoxic effect to monocyte-derived macrophages by activating inflammasome

Hsin-Hung Lin et al.

MICROBIAL PATHOGENESIS (2020)

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Article Biochemistry & Molecular Biology

Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to preventSalmonellainfection

Hitoshi Tsugawa et al.

PLOS BIOLOGY (2020)

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Article Biology

NAIP-NLRC4-deficient mice are susceptible to shigellosis

Patrick S. Mitchell et al.

ELIFE (2020)

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Article Multidisciplinary Sciences

Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway

Zilu Qu et al.

SCIENCE ADVANCES (2020)

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Article Biology

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

Vivek V. Thacker et al.

ELIFE (2020)

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Article Cell Biology

RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly

Yanhui Duan et al.

CELL REPORTS (2020)

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Review Immunology

The gasdermins, a protein family executing cell death and inflammation

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

Jaye M. Platnich et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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Article Multidisciplinary Sciences

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

Andrew Sandstrom et al.

SCIENCE (2019)

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Article Multidisciplinary Sciences

N-terminal degradation activates the NLRP1B inflammasome

Ashley J. Chui et al.

SCIENCE (2019)

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Review Cell Biology

Role of septins in microbial infection

Hoan Van Ngo et al.

JOURNAL OF CELL SCIENCE (2019)

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Review Immunology

Edwardsiella piscicida: A versatile emerging pathogen of fish

Ka Yin Leung et al.

VIRULENCE (2019)

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Article Biochemistry & Molecular Biology

Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis

Daniel Fisch et al.

EMBO JOURNAL (2019)

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Review Immunology

Host Cell Death Responses to Non-typhoidal Salmonella Infection

Madeleine A. Wemyss et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Microbiology

Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features

Joyce E. Karlinsey et al.

CELL HOST & MICROBE (2019)

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Review Immunology

Role of AIM2 inflammasome in inflammatory diseases, cancer and infection

Bhesh Raj Sharma et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2019)

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Article Immunology

Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells

Michelle B. Ryndak et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

Nirmal Robinson et al.

REDOX BIOLOGY (2019)

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Review Cell Biology

Zebrafish in Inflammasome Research

Gabriel Forn-Cuni et al.

CELLS (2019)

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Review Immunology

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

Patrick S. Mitchell et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

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Article Microbiology

Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation

Jayne L. Watson et al.

MBIO (2019)

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Article Microbiology

Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence

Vincenzo Torraca et al.

PLOS PATHOGENS (2019)

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Article Microbiology

Shigella Pathogenesis: New Insights through Advanced Methodologies

Pamela Schnupf et al.

MICROBIOLOGY SPECTRUM (2019)

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Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Cell Biology

Typhoidal Salmonella: Distinctive virulence factors and pathogenesis

Rebecca Johnson et al.

CELLULAR MICROBIOLOGY (2018)

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Review Cell Biology

Use of zebrafish to study Shigella infection

Gina M. Duggan et al.

DISEASE MODELS & MECHANISMS (2018)

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Article Microbiology

Regulation of innate immune functions by guanylate-binding proteins

Gerrit J. K. Praefcke

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2018)

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Review Medicine, General & Internal

Shigellosis

Karen L. Kotloff et al.

LANCET (2018)

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Review Veterinary Sciences

Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review

Emad Hashish et al.

VETERINARY QUARTERLY (2018)

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Article Immunology

Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates

Jiang-yuan Li et al.

JOURNAL OF IMMUNOLOGY (2018)

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Review Immunology

Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection

Krishnaveni Mohareer et al.

TUBERCULOSIS (2018)

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Article Microbiology

Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes

Sina Krokowski et al.

CELL HOST & MICROBE (2018)

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Article Immunology

Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile

Rebecca Johnson et al.

INFECTION AND IMMUNITY (2018)

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Article Biochemistry & Molecular Biology

Salmonella-induced inflammasome activation in humans

Damien Bierschenk et al.

MOLECULAR IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

Peng Li et al.

NATURE (2017)

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Article Microbiology

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

Ryan Finethy et al.

MBIO (2017)

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Article Multidisciplinary Sciences

Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

Pamela P. Lee et al.

NATURE COMMUNICATIONS (2017)

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Article Microbiology

Septins restrict inflammation and protect zebrafish larvae from Shigella infection

Maria J. Mazon-Moya et al.

PLOS PATHOGENS (2017)

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Article Immunology

Identification of an Evolutionarily Conserved Ankyrin Domain Containing Protein, Caiap, Which Regulates Inflammasome-Dependent Resistance to Bacterial Infection

Sylwia D. Tyrkalska et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Microbiology

GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8

Michal P. Wandel et al.

CELL HOST & MICROBE (2017)

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Article Biochemistry & Molecular Biology

Mitochondria mediate septin cage assembly to promote autophagy of Shigella

Andrea Sirianni et al.

EMBO REPORTS (2016)

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Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

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Review Biochemistry & Molecular Biology

Mechanism and Regulation of NLRP3 Inflammasome Activation

Yuan He et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Article Microbiology

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Ruth Wassermann et al.

CELL HOST & MICROBE (2015)

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Editorial Material Cell Biology

Inflammasome assembly: The wheels are turning

Petr Broz

CELL RESEARCH (2015)

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Article Immunology

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux

Sebastian Ruehl et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

Liman Zhang et al.

SCIENCE (2015)

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Article Multidisciplinary Sciences

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

Elena Vigano et al.

NATURE COMMUNICATIONS (2015)

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Review Immunology

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

Serge Mostowy et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Article Microbiology

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

Leigh A. Knodler et al.

CELL HOST & MICROBE (2014)

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Article Multidisciplinary Sciences

Inflammatory caspases are innate immune receptors for intracellular LPS

Jianjin Shi et al.

NATURE (2014)

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Article Biotechnology & Applied Microbiology

Transcriptional analysis of the three Nlrp1 paralogs in mice

Inka Sastalla et al.

BMC GENOMICS (2013)

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Article Microbiology

The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection

Taira Kobayashi et al.

CELL HOST & MICROBE (2013)

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Review Microbiology

Differences in the repertoire, regulation and function of Toll-like Receptors and inflammasome-forming Nod-like Receptors between human and mouse

Juliana K. Ariffin et al.

CURRENT OPINION IN MICROBIOLOGY (2013)

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Article Immunology

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

Shankar S. Iyer et al.

IMMUNITY (2013)

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Article Immunology

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Raul Munoz-Planillo et al.

IMMUNITY (2013)

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Article Immunology

Cutting Edge: Mycobacterium tuberculosis but Not Nonvirulent Mycobacteria Inhibits IFN-β and AIM2 Inflammasome-Dependent IL-1β Production via Its ESX-1 Secretion System

Swati Shah et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Multidisciplinary Sciences

The zebrafish reference genome sequence and its relationship to the human genome

Kerstin Howe et al.

NATURE (2013)

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Article Multidisciplinary Sciences

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Jon A. Hagar et al.

SCIENCE (2013)

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Article Biochemistry & Molecular Biology

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

Vijay A. K. Rathinam et al.

CELL (2012)

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Article Immunology

Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis

Anca Dorhoi et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein

Parimala R. Vajjhala et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Genetics & Heredity

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe

Kathryn E. Holt et al.

NATURE GENETICS (2012)

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Review Cell Biology

Septins: the fourth component of the cytoskeleton

Serge Mostowy et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

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Review Cell Biology

Spatial Guidance of Cell Asymmetry: Septin GTPases Show the Way

Elias T. Spiliotis et al.

TRAFFIC (2012)

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Article Multidisciplinary Sciences

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Yue Zhao et al.

NATURE (2011)

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Article Multidisciplinary Sciences

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

Eric M. Kofoed et al.

NATURE (2011)

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Article Biochemistry & Molecular Biology

The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate

Srirupa Chatterjee et al.

PROTEIN SCIENCE (2011)

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Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

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