期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 462, 期 -, 页码 176-182出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2015.09.068
关键词
Polymer colloids; Thiol-acrylate Michael addition; RAFT polymers; Block copolymers; pH-triggered degradation; Thermosensitive release; Prednisolone
资金
- SRIC, Indian Institute of Technology Kharagpur [IIT/SRIC/CHY/ADA/2014-15/18, IIT/SRIC/CHY/NP A/2014-15/81]
- UGC, New Delhi
- CSIR, New Delhi
Efficient and stimuli-triggered controlled delivery of therapeutics is one of the important issues in modern advanced therapy. In the present work, a versatile route for the synthesis of core cross-linked polymeric nanostructures (CLPN) through thiol-acrylate Michael addition reaction via the formation of beta-thiopropionate has been described. The acid groups of the poly(acrylic acid) block of poly(ethylene glycol)-b-poly(N-isopropylacrylamide)-b-poly(acrylic acid) triblock copolymer were reacted with 2-hydroxyethyl acrylate (HEA) to yield the corresponding acrylate-functionalized copolymer (P1). Following this, P1 was reacted with a thiol functionalized cross-linker (CL) resulting in the formation of core cross-linked polymeric nanoparticles through acrylate-thiol Michael reaction. The ability of these nanoparticles to encapsulate drug molecules inside their core and their effective release following a pH-triggered controlled degradation of the core were demonstrated. The temperature sensitive release behaviour of the system was also studied. The non-toxic nature of the precursor polymers and the core cross-linked polymeric nanoparticles was also established, that further substantiated their potential as carriers for controlled release of drugs. (C) 2015 Elsevier Inc. All rights reserved.
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