Colorectal cold snare polypectomy: Current standard technique and future perspectives

It has been shown that resection of adenomatous colorectal polyps can reduce mortality due to colorectal cancer. In daily clinical practice, simpler and safer methods of colorectal polypectomy have been sought to enable endoscopists to resect all detected lesions. Among these, cold snare polypectomy (CSP) is widely used in clinical practice because of its advantages in shortening procedure time, reducing delayed bleeding risk, and lowering treatment costs, while maintaining a similar complete resection rate for lesions smaller than 10 mm when compared to conventional hot snare polypectomy. This review introduces the findings of previous studies that investigated the efficacy and safety of the CSP procedure for nonpedunculated polyps smaller than 10 mm, and describes technical points to remember when practicing CSP based on the latest evidence, including using a thin wire snare specifically designed for CSP, and observing the surrounding mucosa of the resection site with chromoendoscopy or image-enhanced endoscopy to ensure that there is no residual lesion. This review also describes the potential of expanding the indication of CSP as a treatment for lesions larger than 10 mm, those with pedunculated morphology, those located near the appendiceal orifice, and for patients under continuous antithrombotic agent therapy. Finally, the perspective on optimal treatments for recurrent lesions after CSP is also discussed, despite the limited related evidence and data.

Automated summary

Resection of adenomatous colorectal polyps has been proven to reduce mortality from colorectal cancer. Cold snare polypectomy (CSP) is a simpler and safer method for the resection of colorectal polyps smaller than 10mm, with advantages in shortening procedure time, reducing bleeding risk, and lowering treatment costs compared to conventional methods. This review summarizes previous studies on the efficacy and safety of CSP, as well as discusses potential expansions of its indications and optimal treatments for recurrent lesions.