4.3 Article

INnoVative trial design for testing the Efficacy, Safety and Tolerability of 6-month treatment with incretin-based therapy to prevent type 1 DIAbetes in autoantibody positive participants: A protocol for three parallel double-blind, randomised controlled trials (INVESTDIA)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Endocrinology & Metabolism

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

Bart O. Roep et al.

Summary: Research suggests that type 1 diabetes mellitus is triggered by issues with beta-cells themselves, rather than solely autoimmune attacks on healthy cells. Therefore, treatment should focus on improving the health and function of beta cells, along with immunotherapy, to effectively delay disease progression.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial

Matthias von Herrath et al.

Summary: This study aimed to investigate the combination of anti-interleukin-21 antibody and liraglutide for treating type 1 diabetes, and found that this combination therapy could preserve beta-cell function with a better safety profile compared to traditional immunomodulation methods.

LANCET DIABETES & ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the US

Vibha Anand et al.

Summary: The study shows that the number of islet autoantibodies at seroconversion can reliably predict the 15-year risk of type 1 diabetes. In children with a single autoantibody, HLA-DR-DQ genotypes can further refine the risk of progression. Additionally, the age at which multiple autoantibodies develop can impact the rate of progression to diabetes.

DIABETES CARE (2021)

Article Endocrinology & Metabolism

Randomized 52-week Phase 2 Trial of Albiglutide Versus Placebo in Adult Patients With Newly Diagnosed Type 1 Diabetes

Paolo Pozzilli et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Endocrinology & Metabolism

Decreased Incidence of Type 1 Diabetes in Young Finnish Children

Anna Parviainen et al.

DIABETES CARE (2020)

Article Medicine, General & Internal

Liraglutide in Children and Adolescents with Type 2 Diabetes

William V. Tamborlane et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Medicine, General & Internal

Type 1 diabetes

Linda A. DiMeglio et al.

LANCET (2018)

Review Endocrinology & Metabolism

Biomarkers of islet beta cell stress and death in type 1 diabetes

Emily K. Sims et al.

DIABETOLOGIA (2018)

Review Endocrinology & Metabolism

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

Marian Rewers et al.

CURRENT DIABETES REPORTS (2018)

Review Endocrinology & Metabolism

Understanding and preventing type 1 diabetes through the unique working model of TrialNet

Manuela Battaglia et al.

DIABETOLOGIA (2017)

Article Endocrinology & Metabolism

Reduced β-cell function in early preclinical type 1 diabetes

Maarit K. Koskinen et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2016)

Article Medicine, General & Internal

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

Xavier Pi-Sunyer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

Anette G. Ziegler et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Endocrinology & Metabolism

Diagnosis and Classification of Diabetes Mellitus

DIABETES CARE (2010)

Article Endocrinology & Metabolism

New Definition for the Partial Remission Period in Children and Adolescents with Type 1 Diabetes

Henrik B. Mortensen et al.

DIABETES CARE (2009)

Article Endocrinology & Metabolism

Exendin-4 modulates diabetes onset in nonobese diabetic mice

Irene Hadjiyanni et al.

ENDOCRINOLOGY (2008)

Review Physiology

The physiology of glucagon-like peptide 1

Jens Juul Holst

PHYSIOLOGICAL REVIEWS (2007)