期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 189, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2022.109964
关键词
Cardiovascular autonomic neuropathy; Continuous glucose monitoring; Glucose variability; Heart rate variability; Impaired awareness of hypoglycaemia; Low blood glucose index
资金
- Eli Lilly
- Sanofi
This study assessed the prevalence of cardiovascular autonomic neuropathy (CAN) and the association between glucose variability (GV) and cardiovascular autonomic function in patients with type 1 diabetes (T1DM) and impaired awareness of hypoglycaemia (IAH). The results showed that CAN was present in 35% of the participants and participants with CAN had lower hypoglycaemic parameters. After correction for confounders, there was a significant positive association between hypoglycaemic parameters and cardiovascular autonomic function measures.
Cardiovascular autonomic neuropathy (CAN) is suggested to underlie hypoglycaemic risk in impaired awareness of hypoglycaemia (IAH). We assessed the prevalence of CAN and the association between glucose variability (GV) and cardiovascular autonomic function in patients with type 1 diabetes (T1DM) and IAH. This study is a post-hoc-analysis of results obtained with the IN-CONTROL-trial, designed to assess the effects of continuous glucose monitoring (CGM) on glycaemia. Forty participants (aged 46.4 +/- 11.4 years, diabetes duration 29.1 +/- 13.5 years, HbA1c 7.5 +/- 0.8%(58.2 +/- 8.8 mmol/mol)) underwent 2-week blinded CGM measurements to obtain GV indices. Standardized cardiovascular reflex tests were used to determine the presence of CAN. Cardiovascular autonomic function was assessed with heart rate variability (HRV) measures. 14(35%) participants were classified as having CAN. Participants with CAN had lower percentage time spent in hypoglycaemic range and low blood glucose index(LBGI). After correction for confounders, a significant positive association was found between the coefficient of variation (CV) or time spent in hypoglycaemic range and HRV measures SDRR or RMSSD, and between LBGI and RMSSD. In patients with T1DM and IAH, hypoglycaemic parameters were associated with better cardiovascular autonomic function and lower prevalence of CAN. This suggests that autonomic neuropathy does not seem to further deteriorate hypoglycaemic risk in patients with IAH.
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