The prevalence of metabolic dysfunction-associated fatty liver disease and its association on adverse pregnancy outcomes in women with gestational diabetes mellitus

Aims: To determine the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its as-sociation on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM).Methods: 380 women with GDM had a FibroScan (R) performed between 24 and 32 weeks. A Controlled Attenuation Parameter (CAP) >= 233.5 dB/m signified MAFLD. Gestational hypertension, pre-eclampsia and eclampsia contributed to a composite of adverse maternal outcomes. A composite of adverse neonatal outcomes included pre-term birth, hypoglycaemia, small/large-for-gestational age and admission to neonatal high dependency. Multiple logistic regression was used to determine independent associations with MAFLD.Results: 147 (38.7 %) women had MAFLD. Higher pre-pregnancy BMI (median 28.4, IQR 24.7-33.0 kg/m(2) vs median 24.0, IQR 21.7-26.5 kg/m(2), p < 0.01) and rates of insulin therapy (62.2 % vs 40.7 %, p < 0.01) occurred in MAFLD over non-MAFLD women. MAFLD was independently associated with obesity (aOR 4.73 [95 % CI 2.53-8.86]) and insulin therapy (aOR 1.79 [95 % CI 1.12-2.85]). MAFLD and non-MAFLD women had com-parable rates of adverse maternal (7.7 % vs 9.5 %, p = 0.56) and neonatal outcomes (75.4 % vs 68.8 %, p = 0.18). Conclusions: Within this GDM cohort, almost 40% had FibroScan (R)-detected MAFLD in mid-to-late gestation. MAFLD was not associated with worse pregnancy outcomes.

Automated summary

This study aimed to determine the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its impact on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM). The results showed that almost 40% of women in the GDM cohort had MAFLD detected in mid-to-late gestation. However, MAFLD was not associated with worse pregnancy outcomes.