4.7 Article

Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

Huayi Li et al.

Summary: Breast cancer is a common and deadly cancer in women. Overexpression of PI3KC2 alpha is correlated with high tumor grade and increased distant metastatic events in breast cancer patients. Mechanistically, PI3KC2 alpha synthesis of PI(3,4)P2 at focal adhesions leads to instability, and promotes migration, invasion, and metastasis of breast cancer cells.

ADVANCED SCIENCE (2022)

Article Cell Biology

mTORC1 activity is supported by spatial association with focal adhesions

Yoana Rabanal-Ruiz et al.

Summary: This study enhances our understanding of spatial regulation of mTORC1 by demonstrating that the localization of mTORC1 to focal adhesions is both necessary and sufficient for its activation by growth-promoting stimuli.

JOURNAL OF CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

PI3KC2β inactivation stabilizes VE-cadherin junctions and preserves vascular integrity

Typhaine Anquetil et al.

Summary: Protecting endothelial cells is critical in preventing the impact of vascular leakage and edema on pathological conditions. PI3KC2 beta could be a potential new therapeutic target for treating aggravating lesions following ischemic stroke.

EMBO REPORTS (2021)

Article Cell Biology

Defining the subcellular distribution and metabolic channeling of phosphatidylinositol

Joshua G. Pemberton et al.

JOURNAL OF CELL BIOLOGY (2020)

Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Cell Biology

Biomechanical regulation of focal adhesion and invadopodia formation

Or-Yam Revach et al.

JOURNAL OF CELL SCIENCE (2020)

Review Cell Biology

Regulation of actin dynamics by PI(4,5)P2 in cell migration and endocytosis

Yosuke Senju et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Review Cell Biology

PI3K isoforms in cell signalling and vesicle trafficking

Benoit Bilanges et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Cell Biology

Class II PI3K Functions in Cell Biology and Disease

Federico Gulluni et al.

TRENDS IN CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Phosphoinositides in the control of lysosome function and homeostasis

Michael Ebner et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Review Cell Biology

Phosphoinositide switches in endocytosis and in the endolysosomal system

Haibin Wang et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Review Cell Biology

Microtubules at focal adhesions - a double-edged sword

Shailaja Seetharaman et al.

JOURNAL OF CELL SCIENCE (2019)

Review Cell Biology

Rho GTPase signaling complexes in cell migration and invasion

Campbell D. Lawson et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Cell Biology

The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division

Christina L. Dix et al.

DEVELOPMENTAL CELL (2018)

Article Multidisciplinary Sciences

Frustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structures

Francesco Baschieri et al.

NATURE COMMUNICATIONS (2018)

Article Biochemical Research Methods

TrackMate: An open and extensible platform for single-particle tracking

Jean-Yves Tinevez et al.

METHODS (2017)

Article Cell Biology

Single and collective cell migration: the mechanics of adhesions

Chiara De Pascalis et al.

MOLECULAR BIOLOGY OF THE CELL (2017)

Article Multidisciplinary Sciences

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

Andrea L. Marat et al.

SCIENCE (2017)

Article Cell Biology

Actomyosin contractility and collective migration: may the force be with you

Pahini Pandya et al.

CURRENT OPINION IN CELL BIOLOGY (2017)

Review Cell Biology

Phosphoinositides in Control of Membrane Dynamics

Kay O. Schink et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)

Article Cell Biology

NBR1 enables autophagy-dependent focal adhesion turnover

Candia M. Kenific et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

A phosphoinositide conversion mechanism for exit from endosomes

Katharina Ketel et al.

NATURE (2016)

Article Cell Biology

Control of plasma membrane lipid homeostasis by the extended synaptotagmins

Yasunori Saheki et al.

NATURE CELL BIOLOGY (2016)

Review Cell Biology

Coupling changes in cell shape to chromosome segregation

Nitya Ramkumar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Cell Biology

Rho GTPase signalling in cell migration

Anne J. Ridley

CURRENT OPINION IN CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility

Fabian Feutlinske et al.

NATURE COMMUNICATIONS (2015)

Article Cell Biology

DEPDC1B Coordinates De-adhesion Events and Cell-Cycle Progression at Mitosis

Stefano Marchesi et al.

DEVELOPMENTAL CELL (2014)

Article Cell Biology

The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration

Natalia Schiefermeier et al.

JOURNAL OF CELL BIOLOGY (2014)

Review Cell Biology

Rho GAPs and GEFs Controling switches in endothelial cell adhesion

Jaap D. van Buul et al.

CELL ADHESION & MIGRATION (2014)

Article Multidisciplinary Sciences

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

York Posor et al.

NATURE (2013)

Review Physiology

PHOSPHOINOSITIDES: TINY LIPIDS WITH GIANT IMPACT ON CELL REGULATION

Tamas Balla

PHYSIOLOGICAL REVIEWS (2013)

Article Cell Biology

Assembly and disassembly of cell matrix adhesions

Bernhard Wehrle-Haller

CURRENT OPINION IN CELL BIOLOGY (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

Gerald R. V. Hammond et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis

Kyle R. Legate et al.

EMBO JOURNAL (2011)

Article Cell Biology

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

Christophe Guilluy et al.

NATURE CELL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Type I Phosphatidylinositol Phosphate Kinase Beta Regulates Focal Adhesion Disassembly by Promoting β1 Integrin Endocytosis

Wei-Ting Chao et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Review Cell Biology

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

J. Thomas Parsons et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

PI3K Signaling Through the Dual GTPase-Activating Protein ARAP3 Is Essential for Developmental Angiogenesis

Laure Gambardella et al.

SCIENCE SIGNALING (2010)

Article Cell Biology

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

Ellen J. Ezratty et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2β-AKT pathway

Margaret Das et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

A ROCK inhibitor permits survival of dissociated human embryonic stem cells

Kiichi Watanabe et al.

NATURE BIOTECHNOLOGY (2007)

Article Biochemistry & Molecular Biology

A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling

Zachary A. Knight et al.

Article Biochemistry & Molecular Biology

A pharmacological map of the PI3-K family defines a role for p110 alpha in insulin signaling

Zachary A. Knight et al.

Article Cell Biology

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration

T Maffucci et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Cell Biology

Calpain-mediated proteolysis of talin regulates adhesion dynamics

SJ Franco et al.

NATURE CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

ARAP3 is a PI3K- and rap-regulated GAP for RhoA

S Krugmann et al.

CURRENT BIOLOGY (2004)

Article Cell Biology

ROCK and Dia have opposing effects on adherens junctions downstream of Rho

E Sahai et al.

NATURE CELL BIOLOGY (2002)