4.7 Article

Multifunctional role of GPCR signaling in epithelial tube formation

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Summary: The study reveals that MT-dependent intracellular trafficking regulates apical constriction during salivary gland invagination in Drosophila embryos. Key components involved in protein trafficking, such as Rab11 and Nuclear fallout, are crucial for apicomedial myosin formation and apical constriction. MTs and Rab11 are essential for the apical enrichment of key proteins like Fog ligand, Crumbs, and E-Cadherin, which play a role in coordinating cell behaviors during tubular organ formation.

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