期刊
DERMATOLOGIC THERAPY
卷 35, 期 9, 页码 -出版社
WILEY
DOI: 10.1111/dth.15683
关键词
drug-related side effects and adverse reactions; lymphoma; mechlorethamine; mycosis fungoides; nitrogen mustard compounds; cutaneous T-cell lymphoma
类别
This study evaluated the frequency and potential of gel formulation of chlormethine (CG) for the treatment of mycosis fungoides (MF) through a systematic review and comparison with real-world experience. The results showed that CG gel had a high response rate and good safety in treating MF.
Gel formulation of chlormethine (CG) has gained a preeminent role among therapies available for mycosis fungoides (MF). To evaluate the frequency of use of CG for MF treatment and to determine the limits and potentialities of CG in a real-world setting. A systematic review of articles published prior to October 2021 was performed. Articles were included in the review if a full-text English version was available. MEDLINE (PubMed), Scopus, and Web of Science were each queried from their date of inception with the following terms: mechlorethamine gel, chlormethine gel, and mycosis fungoides. The reference lists of the studies retrieved were searched manually. Moreover, this study included all consecutive patients with different stages of MF (from IA to IIB) who started treatment with CG gel between July 2020 and May 2021. Data of the literature were compared to our single-center real-life experience. Of the surveyed literature, 11 publications were included in the final analysis describing a total of 548 patients with MF. Eleven patients with a median (standard deviation) age of 66 years (15.1) were enrolled and followed up, receiving CG (0.02% chlormethine HCl). Response to treatment resulted higher (90.1%) in our study population than in other real-world experiences published in literature. This systematic review supports the role of CG for MF treatment, showing its limits and potentialities. Our single-center real-life experience revealed an elevated percentage of clinical response with high safety and tolerance, demonstrating its versatile use with dose and application rate adaptability.
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