In vitro study of the antihypertensive, antioxidant and antiproliferative activities of peptides obtained from two varieties of Phaseolus coccineus L

Three biological activities were assessed for peptides obtained from two ayocote bean varieties, antioxidant and antihypertensive properties and antiproliferative activity against MDA breast cancer cells. For the peptides obtained from the ayocote bean black variety the highest antihypertensive activity was obtained with low-molecular weight peptides, principally with those between 5 and 10 kDa. However, for the peptides obtained from ayocote bean purple variety, the highest antihypertensive activity was achieved with peptides with a molecular weight >= 10 kDa, while that the higher antioxidant activity was noted for peptides obtained from ayocote bean purple variety. All peptides from both purple and black ayocote beans varieties inhibited MDA cells proliferation; however, the IC50 was only reached with high concentrations of peptides (2000 or 5000 mu g*mL -1) and exposure times of 12 or 72 h. The obtained results reveal a potential relationship among the antihypertensive, antioxidant activities and anticancer properties of the peptides.

Automated summary

The peptides obtained from different varieties of ayocote beans exhibit antioxidant, antihypertensive, and anticancer activities. The molecular weight of peptides plays a role in their antihypertensive activity, with low-molecular weight peptides being effective for the black variety and high-molecular weight peptides being effective for the purple variety. Peptides from the purple variety have stronger antioxidant activity. All peptides inhibit the proliferation of MDA cells, but high concentrations and longer exposure times are required to reach the IC50.