4.2 Review

Immunotherapy and breast cancer: an overview

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Article Oncology

Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial

C. E. Geyer et al.

Summary: This study demonstrates that the addition of carboplatin to neoadjuvant chemotherapy can improve the pathological complete response rates in patients with triple-negative breast cancer without increasing the risk of side effects or secondary malignancies.

ANNALS OF ONCOLOGY (2022)

Article Oncology

Pathologic complete response (pCR) to neoadjuvant treatment with or without atezolizumab in triple-negative, early high-risk and locally advanced breast cancer: NeoTRIP Michelangelo randomized study*

L. Gianni et al.

Summary: This study aimed to compare the efficacy of different treatment regimens in patients with triple-negative breast cancer. The results showed that the addition of atezolizumab did not significantly increase the rate of pathological complete response (pCR). However, further follow-up for event-free survival (EFS) and molecular studies are still ongoing.

ANNALS OF ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

Durvalumab compared to maintenance chemotherapy in metastatic breast cancer: the randomized phase II SAFIR02-BREAST IMMUNO trial

Thomas Bachelot et al.

Summary: The study found that single-agent antibodies against PD-L1 as maintenance therapy did not significantly benefit the overall population with metastatic breast cancer, but showed improved overall survival in patients with triple-negative breast cancer. Durvalumab may have better sensitivity in patients with CD274 amplification. Analysis of lymphocyte infiltration and homologous recombination deficiency did not predict sensitivity to durvalumab, warranting further research. Maintenance chemotherapy was more effective than durvalumab in patients with hormone receptor-positive and Her2-negative disease.

NATURE MEDICINE (2021)

Article Oncology

Pembrolizumab versus investigator-choice chemotherapy for metastatic triple-negative breast cancer (KEYNOTE-119): a randomised, open-label, phase 3 trial

Eric P. Winer et al.

Summary: Pembrolizumab did not significantly improve overall survival in patients with previously treated metastatic triple-negative breast cancer versus chemotherapy, indicating potential for further research in specific patient subpopulations and combination therapy for this disease.

LANCET ONCOLOGY (2021)

Review Oncology

Paradigms on Immunotherapy Combinations with Chemotherapy

Diego Salas-Benito et al.

Summary: Checkpoint inhibitors are being added to standard-of-care chemotherapy in clinical trials with success reported in various cancer types, but chemotherapy regimens have not been optimized for these combinations; optimal approaches to chemo-immunotherapy should include neoadjuvant and adjuvant schemes to maximize the benefits of both treatments.

CANCER DISCOVERY (2021)

Article Oncology

Pembrolizumab in Patients With Metastatic Breast Cancer With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study

Ajjai S. Alva et al.

Summary: The TAPUR Study aims to identify antitumor activity of targeted agents in advanced cancer patients with specific genomic alterations. Results in a cohort of metastatic breast cancer patients treated with pembrolizumab show significant disease control and objective response rates, supporting the approval of pembrolizumab for certain solid tumors with high tumor mutational burden.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

A. Bardia et al.

Summary: Patients with metastatic triple-negative breast cancer treated with Sacituzumab govitecan had significantly longer progression-free and overall survival compared to standard chemotherapy, but experienced more frequent myelosuppression and diarrhea as adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Oncology

Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

D. Miles et al.

Summary: Combining atezolizumab with paclitaxel did not improve PFS or OS in PD-L1-positive aTNBC patients, although it showed some advantage in unconfirmed best overall response rate and duration of response.

ANNALS OF ONCOLOGY (2021)

Article Oncology

Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells

Daisuke Okajima et al.

Summary: The novel TROP2-directed antibody-drug conjugate (ADC), datopotamab deruxtecan, showed potent antitumor activity and acceptable safety profiles in preclinical models, suggesting it could be a valuable treatment option for patients with TROP2-expressing tumors.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Medicine, General & Internal

Pembrolizumab for Early Triple-Negative Breast Cancer

Peter Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

P. Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

CDK4/6 inhibition triggers anti-tumour immunity

Shom Goel et al.

NATURE (2017)

Article Oncology

Prognostic and predictive value of PDL1 expression in breast cancer

Renaud Sabatier et al.

ONCOTARGET (2015)

Article Pathology

Classical pathology and mutational load of breast cancer - integration of two worlds

Jan Budczies et al.

JOURNAL OF PATHOLOGY CLINICAL RESEARCH (2015)

Review Oncology

The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: a meta-analysis

Ezzeldin M. Ibrahim et al.

BREAST CANCER RESEARCH AND TREATMENT (2014)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)

Article Medicine, Research & Experimental

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Brian D. Lehmann et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)