4.5 Article

Mechanisms and therapeutic targets for neuropathic itch

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Neurosciences

Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch

Tyler S. Nelson et al.

Summary: In summary, the accelerating basic science literature reveals that spinal neuropeptide Y inhibits chronic pain by targeting the Y1 receptor, primarily located in key sites of pain transmission in the dorsal horn. Selective ablation of spinal Y1-INs attenuates hypersensitivity, while pharmacological activation of Y1 inhibits both pain and itch, suggesting Y1-INs as a promising therapeutic target for chronic pain and itch.

PROGRESS IN NEUROBIOLOGY (2021)

Review Medicine, General & Internal

How Do Neurons Signal Itch?

Martin Schmelz

Summary: Recent research findings challenge the traditional view of itch mechanistic theories as mutually exclusive, suggesting that a combination of factors such as neuronal specificity, temporal patterns, and spatial aspects play a role in itch sensation. Understanding the blend of these factors could provide better insights into chronic itch and improve treatment options.

FRONTIERS IN MEDICINE (2021)

Article Rehabilitation

Botulinum toxin type A therapy for bilateral focal neuropathic pruritus in multiple sclerosis: a case report

Diogo M. Portugal et al.

Summary: Neuropathic pruritus is a chronic itch that occurs due to direct damage to the nervous system and is often difficult to treat. In this case, a significant relief of symptoms was achieved through local intradermal injections of botulinum toxin type A in a patient with primary progressive multiple sclerosis and severe bilateral focal pruritus.

INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH (2021)

Article Dermatology

Peripheral Sensitization and Loss of Descending Inhibition Is a Hallmark of Chronic Pruritus

Esther M. Pogatzki-Zahn et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

Article Medicine, General & Internal

A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus

Steven Fishbane et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Dermatology

Generalized chronic itch induced by small-fibre neuropathy: clinical profile and proposed diagnostic criteria

M. P. Pereira et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Review Physiology

PHYSIOLOGY AND PATHOPHYSIOLOGY OF ITCH

Ferda Cevikbas et al.

PHYSIOLOGICAL REVIEWS (2020)

Review Biochemistry & Molecular Biology

Post-Burn Pruritus

Bo Young Chung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

Nppb Neurons Are Sensors of Mast Cell-Induced Itch

Hans Jurgen Solinski et al.

CELL REPORTS (2019)

Article Neurosciences

How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch

Martina Pagani et al.

NEURON (2019)

Article Multidisciplinary Sciences

Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray

Vijay K. Samineni et al.

NATURE COMMUNICATIONS (2019)

Article Dermatology

Course and Predictors of Pruritus Following Burns: A Multilevel Analysis

Kelly A. A. Kwa et al.

ACTA DERMATO-VENEREOLOGICA (2018)

Editorial Material Dermatology

Cooling the Itch via TRPM8

Boyi Liu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Medicine, Research & Experimental

A disease mutation reveals a role for NaV1.9 in acute itch

Juan Salvatierra et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Letter Dermatology

The role of topical anesthetics in the management of chronic pruritus

Alice He et al.

JOURNAL OF DERMATOLOGICAL TREATMENT (2017)

Article Dermatology

Novel TRPM8 agonist cooling compound against chronic itch: results from a randomized, double-blind, controlled, pilot study in dry skin

S. Staender et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

Article Neurosciences

Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin

F. Ru et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

Review Medicine, Research & Experimental

Research progress of capsaicin responses to various pharmacological challenges

Pompy Patowary et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Biochemistry & Molecular Biology

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Landon K. Oetjen et al.

Article Dermatology

Meralgia paresthetica successfully treated with topical 0.1% tacrolimus: a case report

Carina M. Groenhagen et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2016)

Article Dermatology

Use of transcutaneous electrical nerve stimulation for chronic pruritus

Basma Mourad Mohammad Ali et al.

DERMATOLOGIC THERAPY (2015)

Article Biochemistry & Molecular Biology

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Miho Shiratori-Hayashi et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

Steeve Bourane et al.

SCIENCE (2015)

Review Clinical Neurology

Neuropathic pruritus

Laurent Misery et al.

NATURE REVIEWS NEUROLOGY (2014)

Review Neurosciences

Sensory neurons and circuits mediating itch

Robert H. LaMotte et al.

NATURE REVIEWS NEUROSCIENCE (2014)

Article Anesthesiology

Paroxysmal itch caused by gain-of-function Nav1.7 mutation

Grazia Devigili et al.

Article Multidisciplinary Sciences

Three functionally distinct classes of C-fibre nociceptors in primates

Matthew Wooten et al.

NATURE COMMUNICATIONS (2014)

Review Pharmacology & Pharmacy

Mas and Its Related G Protein-Coupled Receptors, Mrgprs

Michael Bader et al.

PHARMACOLOGICAL REVIEWS (2014)

Article Dermatology

Neuropathic itch: diagnosis and management

Astrid Stumpf et al.

DERMATOLOGIC THERAPY (2013)

Editorial Material Neurosciences

Scratching an itch

Barbara Namer et al.

NATURE NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

The Cells and Circuitry for Itch Responses in Mice

Santosh K. Mishra et al.

SCIENCE (2013)

Editorial Material Dermatology

Topical Amitriptyline-Ketamine for the Treatment of Brachioradial Pruritus

Timothy J. Poterucha et al.

JAMA DERMATOLOGY (2013)

Article Neurosciences

Mechanisms of Itch Evoked by β-Alanine

Qin Liu et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Anesthesiology

The Effects of Intrathecal and Systemic Gabapentin on Spinal Substance P Release

Toshifumi Takasusuki et al.

ANESTHESIA AND ANALGESIA (2011)

Letter Dermatology

Botulinum toxin type A for neuropathic itch

J. Wallengren et al.

BRITISH JOURNAL OF DERMATOLOGY (2010)

Review Behavioral Sciences

Itch and pain

Martin Schmelz

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2010)

Review Neurosciences

The neurobiology of itch

Akihiko Ikoma et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Article Dermatology

Medical Pearl: The ice-pack sign in brachioradial pruritus

JD Bernhard et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2005)

Article Dermatology

Pruritus, pain, and small nerve fiber function in keloids: A controlled study

SS Lee et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2004)