期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 75, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2022.102573
关键词
Neuropathic pruritus; Chronic pruritus; Neuronal sensitization; Patho-physiology; Therapy
资金
- German Research Foundation (Deutsche Forschungsgesellschaft, DFG) [FOR2690]
Neuropathic pruritus conditions result from damage to the nervous system, and novel findings strengthen the specificity theory of pruritus transmission. Activation of nociceptors and specific discharge patterns of primary afferents also contribute to itch development. Interactions between excitatory and inhibitory interneurons, non-neuronal cells, and descending modulation from upper centers contribute to neuronal sensitization, leading to chronic itch and accompanying phenomena.
Neuropathic pruritus conditions arise from structural and/or functional damage of the peripheral or central nervous system. Novel findings of pruritus specific mediators and pathways strengthen the specificity theory of pruritus transmission, however electrophysiological studies suggest that focal activation of nociceptors and distinct discharge patterns of primary afferents also contribute to the development of the sensation of pruritus. A complex interplay between excitatory and inhibitory interneurons at spinal level, non-neuronal cells and descending modulation from upper centers contributes to neuronal sensitization and clinically to the chronicity of pruritus, as well as accompanying phenomena such as alloknesis and hyperknesis. Several topical, systemic and non pharmacological therapeutic approaches directed at distinct targets are currently available.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据