Mechanosensitive body-brain interactions in Caenorhabditis elegans

Proprioception and visceral mechanosensation provide important information about the location and deformation of the body parts in space and time. These deformations arise from muscle contraction during locomotion, but also from volume changes in organs that are subjected to stresses as a part of their physiological function. These internal morphodynamics give rise to periodic contraction???relaxation cycles with surprisingly constant amplitudes and the maintenance of these optimal driving patterns is remarkably robust against external and internal perturbations. One of the underlying reason for this robustness is an internal feedback mechanism in which specialized sensory cells and neurons signal the mechanical deformation of the inner workings of our organs, from the body to the brain, which subsequently adjust the driver to a predetermined physiological setpoint. Here, we review recent progress in the field of visceral mechanosensation and proprioception in Caenorhabditis elegans and discuss how future studies with this model can be used to gain insight into mechanosensory body???brain interactions in mammals.

Automated summary

This article discusses the importance of proprioception and visceral mechanosensation in providing information about the location and deformation of body parts. It highlights the crucial role of an internal feedback mechanism in maintaining optimal driving patterns and proposes the use of Caenorhabditis elegans as a model for future studies on body-brain interactions in mammals.