期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 75, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2022.102557
关键词
-
资金
- National Institutes of Health [5 R35 GM136337-02]
- Commonwealth Universal Research Enhancement Formula (CURE) grant from Pennsylvania Department of Health [SAP 4100085747]
Septins play a crucial role in neurogenesis by controlling membrane domain localization and regulating the cytoskeletal proteins to promote axon-dendrite formation and stability.
Neuronal morphogenesis is guided by outside-in signals and inside-out mechanisms, which require spatiotemporal precision. How the intracellular mechanisms of neuronal morphogenesis are spatiotemporally controlled is not well understood. Septins comprise a unique GTPase module, which consists of complexes with differential localizations and functions. Septins demarcate distinct membrane domains in neural precursor cells, orienting the axis of cell division and the sites of neurite formation. By controlling the localization of membrane and cytoskeletal proteins, septins promote axon-dendrite formation and polarity. Furthermore, septins modulate vesicle exocytosis at pre-synaptic terminals, and stabilize dendritic spines and post-synaptic densities in a phospho-regulatable manner. We posit that neuronal septins are topologically and functionally specialized for the spatiotemporal regulation of neuronal morphogenesis and plasticity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据