4.1 Review

Esophageal adenocarcinoma phenotypes and risk factors

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Article Gastroenterology & Hepatology

Prevalence of Barrett's esophagus and performance of societal screening guidelines in an unreferred primary care population of US veterans

Theresa H. Nguyen et al.

Summary: This study examined the prevalence of Barrett's esophagus in a previously unscreened primary care population and evaluated the performance of various BE screening guidelines. The findings suggest that guidelines requiring GERD symptoms have low sensitivity, while those not requiring GERD have low specificity. The study proposes a screening guideline with better utilization of known risk factors.

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Risk Factor Profiles Can Distinguish Esophageal Adenocarcinoma From Barrett's Esophagus

Tarek Sawas et al.

Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.

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Computational modelling suggests that Barrett's oesophagus may be the precursor of all oesophageal adenocarcinomas

Kit Curtius et al.

Summary: The study aimed to determine whether Barrett's esophagus is the origin of all incident esophageal adenocarcinomas, and found that almost all cases of OAC could be attributed to Barrett's esophagus based on a computational model and population data.
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Comparative Cost Effectiveness of Reflux-Based and Reflux-Independent Strategies for Barrett's Esophagus Screening

Sarmed S. Sami et al.

Summary: In GERD-independent scenarios, most non-sEGD BE screening tests were cost-effective, with swallowable esophageal cell collection devices with biomarkers being the optimal choice. However, exhaled volatile organic compounds had the highest ICERs in all scenarios.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Review Oncology

Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma

Sascha Hoppe et al.

Summary: Esophageal adenocarcinoma (EAC) is a deadly disease with limited options for targeted therapy. Next-generation sequencing studies have provided insights into the genomic complexity of EAC, revealing high burden of point mutations and genomic rearrangements, which hamper targeted therapies. The development of personalized treatment may benefit from dividing EAC patients into different subgroups based on their gene mutations and gene activity changes.

CANCERS (2021)

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Comparison of Phenotypes and Risk Factors for Esophageal Adenocarcinoma at Present vs Prior Decades

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HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer (vol 117, pg 451, 2017)

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The Effect of Endoscopic Surveillance in Patients With Barrett's Esophagus: A Systematic Review and Meta-analysis

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Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults by Sex and Age, 2007-2008 to 2015-2016

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Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts

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The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma

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Oesophageal cancer

Elizabeth C. Smyth et al.

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The Impact of a Prior Diagnosis of Barrett's Esophagus on Esophageal Adenocarcinoma Survival

Angela C. Tramontano et al.

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ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus

Nicholas J. Shaheen et al.

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Metabolic Syndrome Increases Risk of Barrett Esophagus in the Absence of Gastroesophageal Reflux An Analysis of SEER-Medicare Data

Jennifer Drahos et al.

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Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

Katia Nones et al.

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Association Between Markers of Obesity and Progression From Barrett's Esophagus to Esophageal Adenocarcinoma

Catherine Duggan et al.

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Preoperative prevalence of Barrett's esophagus in esophageal adenocarcinoma: A systematic review

GS Dulai et al.

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