☆ 4.3 Review

Update on glucose control during and after critical illness

CURRENT OPINION IN CRITICAL CARE (2022)

相关参考文献

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Article Endocrinology & Metabolism

Association between dysglycemia and mortality by diabetes status and risk factors of dysglycemia in critically ill patients: a retrospective study

Haoming Ma et al.

Summary: The study found that the association between the three dimensions of dysglycemia and mortality varied by diabetes status in critically ill patients, indicating that glucose management should be specific to the patient's needs considering the diabetes status and broader dimensions.

ACTA DIABETOLOGICA (2022)

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Article Critical Care Medicine

Relative Hypoglycemia and Lower Hemoglobin A1c-Adjusted Time in Band Are Strongly Associated With Increased Mortality in Critically Ill Patients

James S. Krinsley et al.

Summary: This study investigated the association of relative hypoglycemia and hemoglobin A1c-adjusted time in blood glucose band with mortality in critically ill patients, finding that blood glucose values in the range of 70-110 may be harmful for patients with HbA1c greater than or equal to 8.0%.

CRITICAL CARE MEDICINE (2022)

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Review Endocrinology & Metabolism

Nutritional therapy in critically ill patients with diabetes

Ra'eesa Doola et al.

Summary: There has been a significant increase in nutrition therapy related studies within the critical care cohort in recent years. The use of diabetes-specific formulae in critically ill patients with pre-existing diabetes and stress hyperglycaemia can be considered a logical approach to minimize the risks associated with high doses of insulin. Additional research is required to address the effects of these formulae on the dysglycaemia, nursing workload, safety of glycaemic control and cost-effectiveness.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2022)

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Article Endocrinology & Metabolism

Telemetric Continuous Glucose Monitoring During the COVID-19 Pandemic in Isolated Hospitalized Patients in Denmark: A Randomized Controlled Exploratory Trial

Carina Kirstine Klarskov et al.

Summary: This study found that remote glucose monitoring using CGM did not lead to better glycemic control compared to traditional point-of-care glucose testing in hospitalized and isolated patients. However, it was associated with fewer interactions between patients and healthcare workers, saving time for the healthcare staff. The majority of healthcare personnel preferred CGM over traditional glucose testing.

DIABETES TECHNOLOGY & THERAPEUTICS (2022)

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Article Endocrinology & Metabolism

Stress Hyperglycemia Is Associated With an Increased Risk of Subsequent Development of Diabetes Among Bacteremic and Nonbacteremic Patients

Xiansong Wang et al.

Summary: Transient stress hyperglycemia in hospitalized patients is associated with a higher risk of subsequent diabetes development, regardless of the presence of bacteremia or nonbacteremic diseases.

DIABETES CARE (2022)

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Article Endocrinology & Metabolism

Use of a Continuous Glucose Monitoring System in High-Risk Hospitalized Noncritically Ill Patients With Diabetes After Cardiac Surgery and During Their Transition of Care From the Intensive Care Unit During COVID-19: A Pilot Study

Ann T. Sweeney et al.

Summary: We conducted a pilot feasibility study during the COVID-19 pandemic to assess the feasibility and accuracy of real-time CGM in patients with diabetes undergoing cardiac surgery and transitioning from the ICU. The results showed that CGM has great potential in optimizing inpatient diabetes management with high clinical reliability and accuracy after the transition of care.

ENDOCRINE PRACTICE (2022)

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Article Critical Care Medicine

Insulin therapy associated relative hypoglycemia during critical illness

Timothy N. Kwan et al.

Summary: This study investigated the epidemiology and outcomes of relative hypoglycemia (RH) in critically ill diabetes patients receiving insulin therapy. The results showed that RH was common in insulin-treated patients and associated with poorer glycemic control, but not mortality.

JOURNAL OF CRITICAL CARE (2022)

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Article Critical Care Medicine

Survivors of Intensive Care With Type 2 Diabetes and the Effect of Shared-Care Follow-Up Clinics The SWEET-AS Randomized Controlled Pilot Study

Yasmine Ali Abdelhamid et al.

Summary: This study investigated the effects of a shared-care clinic for ICU survivors with type 2 diabetes, showing low participation and high mortality rates. The intervention did not significantly improve outcomes for this cohort.

CHEST (2021)

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Review Critical Care Medicine

Global Impact of Coronavirus Disease 2019 Infection Requiring Admission to the ICU A Systematic Review and Meta-analysis

Elinor Tan et al.

Summary: The systematic review and meta-analysis included 45 studies from 17 countries across four continents, involving 16,561 patients with severe COVID-19 admitted to ICUs. The study revealed that critically ill COVID-19 patients require substantial organ support, with a high mortality rate of 28.1% during hospitalization.

CHEST (2021)

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Letter Endocrinology & Metabolism

Proportion of newly diagnosed diabetes in COVID-19 patients: A systematic review and meta-analysis

Thirunavukkarasu Sathish et al.

DIABETES OBESITY & METABOLISM (2021)

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Article Endocrinology & Metabolism

COVID-19, Hyperglycemia, and New-Onset Diabetes

Kamlesh Khunti et al.

Summary: New-onset diabetes is common among COVID-19 patients and may impact disease severity and outcomes. The underlying mechanisms are complex and require further research. Hospitals should prioritize identification and management of acute hyperglycemia.

DIABETES CARE (2021)

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Article Critical Care Medicine

Nocturnal Hypoglycemia in Patients With Diabetes Discharged From ICUs: A Prospective Two-Center Cohort Study*

Yasmine Ali Abdelhamid et al.

Summary: Hypoglycemia is common in ICU survivors with type-2 diabetes, especially during the night, and is often asymptomatic and prolonged. While hypoglycemia was associated with an increased risk of bradycardia, it did not impact atrial or ventricular ectopics, heart rate variability, or cardiac repolarization.

CRITICAL CARE MEDICINE (2021)

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Article Endocrinology & Metabolism

Remote Continuous Glucose Monitoring With a Computerized Insulin Infusion Protocol for Critically Ill Patients in a COVID-19 Medical ICU: Proof of Concept

Georgia M. Davis et al.

Summary: The study shows that a hybrid protocol integrating CGM and POC is helpful for managing critically ill patients with COVID-19 requiring insulin infusion. Sensor accuracy is impacted by mechanical interferences, but the majority of sensor values are within 20% of reference POC glucose levels.

DIABETES CARE (2021)

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Review Nutrition & Dietetics

Endogenous glucose production in critical illness

Nameer Al-Yousif et al.

Summary: Regulation of endogenous glucose production is crucial for maintaining euglycemia, but critical illness can disrupt this process through various mechanisms such as inflammation, hormonal imbalances, and insulin resistance, which can lead to hyperglycemia and hypoglycemia, impacting patient outcomes. Understanding these mechanisms may help develop therapeutic strategies to improve outcomes in critical illness.

NUTRITION IN CLINICAL PRACTICE (2021)

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Article Nutrition & Dietetics

The goldilocks problem: Nutrition and its impact on glycaemic control

Jennifer L. Knopp et al.

Summary: This study investigated the impact of nutritional management on blood glucose outcomes in intensive care, finding that coordination of nutrition and insulin therapy is crucial for effective glycemic control. Results suggest that adjusting nutrition alongside insulin can improve glycemic control, particularly in patients with persistent hyperglycemia or low glucose tolerance.

CLINICAL NUTRITION (2021)

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Article Nutrition & Dietetics

Association of specialized enteral nutrition with glycemic control and clinical outcomes in critically ill patients: A meta-analysis of randomized controlled trials

Igor Eckert et al.

Summary: The study found that glycemic-control formulae were associated with better blood sugar control and lower insulin requirements in critically ill patients, but the results for clinical outcomes were not statistically significant. There was insufficient evidence to confirm important differences due to low quality of evidence.

CLINICAL NUTRITION (2021)

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Article Health Care Sciences & Services

A comparison of arterial blood glucose and peripheral blood glucose levels in critically ill patients: measurements using the arterial blood gas analyzer and the rapid glucose meter

Ting Deng et al.

Summary: This study compared blood glucose levels measured using an arterial blood gas analyzer and a rapid blood glucose meter in critically ill patients. The results showed significant differences between the two methods, but good agreement overall. The maximum absolute difference of 2.30 mmol/L within the agreement range suggests clinical acceptability.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Computer Science, Interdisciplinary Applications

The development of a glucose prediction model in critically ill patients

M. van den Boorn et al.

Summary: The aim of the study was to develop a glucose prediction model applicable for all ICU patients with an expected stay of at least 24 hours. The model, based on historical glucose data, showed promising accuracy in predicting glucose levels 30 minutes ahead, marking a significant step in the development of a closed-loop glucose system.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2021)

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Editorial Material Critical Care Medicine

The goal of personalized glucose control in the critically ill remains elusive

James S. Krinsley et al.

INTENSIVE CARE MEDICINE (2021)

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Article Anesthesiology

Glucose control using an artificial pancreas in a severe COVID-19 patient on extracorporeal membrane oxygenation: a case report

Takuya Hinoue et al.

Summary: The use of continuous glucose monitoring (CGM) systems in adult patients with severe coronavirus disease (COVID-19) has been reported to be useful and safe. A closed-loop device, such as the STG-55, showed potential utility in controlling glucose levels in a critically ill patient with severe COVID-19.

JOURNAL OF ANESTHESIA (2021)

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Article Endocrinology & Metabolism

Use of Continuous Glucose Monitor in Critically Ill COVID-19 Patients Requiring Insulin Infusion: An Observational Study

Eileen R. Faulds et al.

Summary: This study provides data to support the feasibility, accuracy, safety, and potential workload reduction of using CGM with a hybrid protocol in the ICU for patients with COVID-19 on IV insulin therapy.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Critical Care Medicine

Outcomes and adverse effects of extremely high dose insulin infusions in ICU patients

Arianna J. Vidger et al.

Summary: This study examined the characteristics, hospital course, and outcomes of adult ICU patients receiving extremely high dose insulin infusions compared to those with lower insulin requirements. Patients with extremely high dose insulin infusions were more likely to experience hypoglycemia, took longer to achieve glucose control, and had higher mortality rates than those with lower requirements. Individualized management approaches may be necessary for patients with extremely high insulin needs.

JOURNAL OF CRITICAL CARE (2021)

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Article Medicine, General & Internal

A prospective six-month audit of inpatient hypoglycemia in step-down general medical and geriatric wards

Penny Dwyer et al.

Summary: The study evaluated the incidence and associated factors of hypoglycemia in patients transferred from an Acute Medical Unit to general medical or geriatric wards in an Australian hospital. The data showed a relatively high rate of hypoglycemia in stable inpatients, often occurring at night and with a significant proportion of severe cases.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

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Article Critical Care Medicine

Results of a Multicenter Feasibility Study of an Automated Bedside Glucose Monitoring System in the Burn Intensive Care Setting

Craig T. Elder et al.

JOURNAL OF BURN CARE & RESEARCH (2020)

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Letter Anesthesiology

Blood glucose control management in critically ill adult patients: Results of a French nationwide practice survey

Sebastien Pili-Floury et al.

ANAESTHESIA CRITICAL CARE & PAIN MEDICINE (2020)

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Article Critical Care Medicine

The Interaction of Acute and Chronic Glycemia on the Relationship of Hyperglycemia, Hypoglycemia, and Glucose Variability to Mortality in the Critically Ill*

James S. Krinsley et al.

CRITICAL CARE MEDICINE (2020)

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Article Endocrinology & Metabolism

Accuracy of Blood Glucose Measurement and Blood Glucose Targets

Gert-Jan Eerdekens et al.

JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY (2020)

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Article Medicine, General & Internal

Glucometric benchmarking in an Australian hospital enabled by networked glucose meter technology

Mervyn Kyi et al.

MEDICAL JOURNAL OF AUSTRALIA (2019)

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Article Critical Care Medicine

Incident Diabetes in Survivors of Critical Illness and Mechanisms Underlying Persistent Glucose Intolerance: A Prospective Cohort Study

Palash Kar et al.

CRITICAL CARE MEDICINE (2019)

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Article Critical Care Medicine

Opinions and practices of blood glucose control in critically ill patients with pre-existing type 2 diabetes in Australian and New Zealand intensive care units

Alexis P. Poole et al.

AUSTRALIAN CRITICAL CARE (2019)

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Article Critical Care Medicine

Are point-of-care measurements of glycated haemoglobin accurate in the critically ill?

Luke M. Weinel et al.

AUSTRALIAN CRITICAL CARE (2019)

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Article Anesthesiology

Hospital-acquired complications in intensive care unit patients with diabetes: A before-and-after study of a conventional versus liberal glucose control protocol

Nora Luethi et al.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2019)

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Article Critical Care Medicine

\ Liberal Glucose Control in ICU Patients With Diabetes: A Before-and-After Study

Nora Luethi et al.

CRITICAL CARE MEDICINE (2018)

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Article Critical Care Medicine

Near-Continuous Glucose Monitoring Makes Glycemic Control Safer in ICU Patients

Jean-Charles Preiser et al.

CRITICAL CARE MEDICINE (2018)

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Article Endocrinology & Metabolism

Glycated haemoglobin is increased in critically ill patients with stress hyperglycaemia: Implications for risk of diabetes in survivors of critical illness

Yang T. Du et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Review Engineering, Biomedical

Current status and issues of the artificial pancreas: abridged English translation of a special issue in Japanese

Tsutomu Namikawa et al.

JOURNAL OF ARTIFICIAL ORGANS (2018)

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Review Critical Care Medicine

Systematic review of incretin therapy during peri-operative and intensive care

Abraham H. Hulst et al.

CRITICAL CARE (2018)

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Article Medicine, General & Internal

Glucose Control, Diabetes Status, and Mortality in Critically Ill Patients: The Continuum From Intensive Care Unit Admission to Hospital Discharge

James S. Krinsley et al.

MAYO CLINIC PROCEEDINGS (2017)

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Review Critical Care Medicine

Continuous glucose monitoring in the ICU: clinical considerations and consensus

James S. Krinsley et al.

CRITICAL CARE (2017)

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Article Respiratory System

Dysglycemia and Glucose Control During Sepsis

Mark P. Plummer et al.

CLINICS IN CHEST MEDICINE (2016)

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Article Critical Care Medicine

Liberal Glycemic Control in Critically III Patients With Type 2 Diabetes: An Exploratory Study

Palash Kar et al.

CRITICAL CARE MEDICINE (2016)

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Article Multidisciplinary Sciences

Stress Induced Hyperglycemia and the Subsequent Risk of Type 2 Diabetes in Survivors of Critical Illness

Mark P. Plummer et al.

PLOS ONE (2016)

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Review Critical Care Medicine

Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis

Yasmine Ali Abdelhamid et al.

CRITICAL CARE (2016)

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Article Critical Care Medicine

Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality

Mark P. Plummer et al.

INTENSIVE CARE MEDICINE (2014)

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Article Critical Care Medicine

The evaluation of the ability of closed-loop glycemic control device to maintain the blood glucose concentration in intensive care unit patients

Tomoaki Yatabe et al.

CRITICAL CARE MEDICINE (2011)

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Article Medicine, General & Internal

Intensive versus Conventional Glucose Control in Critically Ill Patients

S. Finfer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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