期刊
CURRENT OPINION IN CELL BIOLOGY
卷 77, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2022.102089
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资金
- Deutsche Forschungsgemeinschaft (DFG) [SPP 2191, 419138182]
- Max Planck Society
This review discusses the role of phase separation of multivalent proteins in the assembly of cellular junctional complexes and summarizes recent evidence.
Epithelial junctions are transmembrane protein complexes that regulate cell adhesion, cell polarity, tissue permeability, and tissue mechanics. Most junctional complexes contain membrane attached cytoplasmic plaques that regulate junction assembly and are composed of multivalent scaffold proteins. In this review, we discuss phase separation of multivalent proteins as a general process that drives assembly of many membrane-less cellular compartments. And we summarise recent evidence that phase separation of junctional scaffold proteins is involved in the assembly of tight junctions and focal adhesions.
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