期刊
CURRENT OPINION IN CELL BIOLOGY
卷 77, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2022.102105
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资金
- Children's Discovery Institute of Washington University
- St. Louis Children's Hospital [CDI-CORE2015-505, CDI-CORE-2019-813]
- Foundation for BarnesJewish Hospital [3770, 4642]
- National Heart, Lung and Blood Institute [R01HL128370]
- National Institute of Diabetes and Digestive and Kidney Diseases [R01-DK108005]
- Department of Defense e Congressionally Directed Medical Research Programs [W81XWH-20-1-0198]
This review discusses recent progress in understanding the mechanisms of centriole and cilia biogenesis in multiciliated cells (MCC), and explores how MCC progenitor cells regulate the number of centrioles and cilia during their differentiation.
Multiciliated cells (MCC) are evolutionary conserved, highly specialized cell types that contain dozens to hundreds of motile cilia that they use to propel fluid directionally. To template these cilia, each MCC produces between 30 and 500 basal bodies via a process termed centriole amplification. Much progress has been made in recent years in understanding the pathways involved in MCC fate determination, differentiation, and ciliogenesis. Recent studies using mammalian cell culture systems, mice, Xenopus, and other model organisms have started to uncover the mechanisms involved in centriole and cilia biogenesis. Yet, how MCC progenitor cells regulate the precise number of centrioles and cilia during their differentiation remains largely unknown. In this review, we will examine recent findings that address this fundamental question.
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