4.8 Article

Mushroom body input connections form independently of sensory activity in Drosophila melanogaster

期刊

CURRENT BIOLOGY
卷 32, 期 18, 页码 4000-+

出版社

CELL PRESS
DOI: 10.1016/j.cub.2022.07.055

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资金

  1. National Institute of Neurological Disorders and Stroke [R01 NS 106018, R01 NS 1079790, R01 EB 029858]
  2. National Science Foundation [IOS 2042397, DBI 1707398]
  3. Gatsby Charitable Foundation
  4. DOE CSGF [DE-SC0022158]
  5. University Research Opportunities Program
  6. Burroughs Wellcome Fund
  7. McKnight Endowment Fund
  8. Simons Collaboration on the Global Brain
  9. Georges S. and Dolores Eccles Foundation
  10. U.S. Department of Energy (DOE) [DE-SC0022158] Funding Source: U.S. Department of Energy (DOE)

向作者/读者索取更多资源

The connectivity pattern between the Kenyon cells and projection neurons in the insect mushroom body can be encoded by fixed genetic programs, and this pattern may be the result of evolved prioritization of ecologically and ethologically salient stimuli.
Associative brain centers, such as the insect mushroom body, need to represent sensory information in an efficient manner. In Drosophila melanogaster, the Kenyon cells of the mushroom body integrate inputs from a random set of olfactory projection neurons, but some projection neurons-namely those activated by a few ethologically meaningful odors-connect to Kenyon cells more frequently than others. This biased and random connectivity pattern is conceivably advantageous, as it enables the mushroom body to repre-sent a large number of odors as unique activity patterns while prioritizing the representation of a few specific odors. How this connectivity pattern is established remains largely unknown. Here, we test whether the mechanisms patterning the connections between Kenyon cells and projection neurons depend on sensory activity or whether they are hardwired. We mapped a large number of mushroom body input connections in partially anosmic flies-flies lacking the obligate odorant co-receptor Orco-and in wild-type flies. Statis-tical analyses of these datasets reveal that the random and biased connectivity pattern observed between Kenyon cells and projection neurons forms normally in the absence of most olfactory sensory activity. This finding supports the idea that even comparatively subtle, population-level patterns of neuronal connec-tivity can be encoded by fixed genetic programs and are likely to be the result of evolved prioritization of ecologically and ethologically salient stimuli.

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