期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2022.2108370
关键词
Aptamer; food safety; sensor; surface-enhanced Raman scattering (SERS); review
资金
- Innovation and Entrepreneurship Projects
- Six Talent Peaks Project of Jiangsu Province [SWYY-023]
- National Natural Science Foundation of China [21603087]
- High-level Overseas Talent Workstation of Shandong Province
Aptamer sensors, based on molecular interactions, have been extensively studied for their ability to specifically identify food contaminants. The integration of surface-enhanced Raman spectroscopy with aptamers offers advantages in sensitivity and speed. These sensors have applications in detecting biological and chemical contamination in food.
It is well known that food safety has aroused extensive attentions from governments to researchers and to food industries. As a versatile technology based on molecular interactions, aptamer sensors which could specifically identify a wide range of food contaminants have been extensively studied in recent years. Surface-enhanced Raman spectroscopy integrated aptamer combines the advantages of both technologies, not only in the ability to specifically identify a wide range of food contaminants, but also in the ultra-high sensitivity, simplicity, portable and speed. To provide beneficial insights into the evaluation techniques in the field of food safety, we offer a comprehensive review on the design strategies for aptamer-SERS sensors in different scenarios, including non-nucleic acid amplification methods (on/off mode, sandwich mode, competition model and catalytic model) and nucleic acid amplification methods (hybridization chain reaction, rolling circle amplification, catalytic hairpin assembly). Meanwhile, a special attention is paid to the application of aptamer-SERS sensors in biological (foodborne pathogenic, bacteria and mycotoxins) and chemical contamination (drug residues, metal ions, and food additives) of food matrix. Finally, the challenges and prospects of developing reliable aptamer-SERS sensors for food safety were discussed, which are expected to offer a strong guidance for further development and extended applications.
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