Advances in C1-deuterated aldehyde synthesis

The recent surge in deuterated pharmaceutical compounds has created an urgent demand for new synthetic tools that allow facile access to D-containing building blocks. As one of the most predominant chemical entities in organic synthesis, aldehyde serves as a powerful linchpin in assembling structurally diverse molecular architectures. Recently, numerous efforts have been devoted to developing synthetic methods toward C1-deuterated aldehydes, which apparently broaden and streamline approaches toward versatile deuterated compounds. Herein, our aim is to offer a timely and comprehensive survey of this emerging topic. The overview is divided into four sections according to the synthesis tool utilized, with specific emphasis placed on the reaction design, mechanistic pathway, and resulting new synthetic paradigms. (c) 2022 Elsevier B.V. All rights reserved.

Automated summary

The recent increase in the use of deuterated compounds in pharmaceuticals has created a need for new synthetic tools to easily access D-containing building blocks. Aldehydes, as one of the most important chemical entities in organic synthesis, play a crucial role in assembling structurally diverse molecules. Recent efforts have focused on developing synthetic methods for C1-deuterated aldehydes, which expand and streamline approaches to versatile deuterated compounds. This article aims to provide a timely and comprehensive survey of this emerging topic, divided into four sections based on the synthetic tools used, with specific emphasis on reaction design, mechanistic pathway, and resulting new synthetic paradigms.