期刊
CONTRAST MEDIA & MOLECULAR IMAGING
卷 2022, 期 -, 页码 -出版社
WILEY-HINDAWI
DOI: 10.1155/2022/3912376
关键词
-
资金
- Youth Research Fund from the Health and Family Planning Commission of Fujian Province [2017-1-34]
The aim of this study was to investigate the clinical and electrical characteristics as well as prognosis in patients with lung cancer and Lambert-Eaton myasthenic syndrome (LEMS). The study found that LEMS usually occurs before lung cancer, and it is more common in men. Most patients experienced nervous system lesions prior to the occurrence of lung cancer.
The aim is to study lung cancer with Lambert-Eaton myasthenic syndrome (LEMS) with clinical and electrical characteristics of physiology and prognosis. Fourteen LEMS patients with lung cancer were studied retrospectively. The data including demographics, clinical presentation, treatments, and prognosis from the medical records were analyzed. Lung cancer coexisting with LEMS is more common in men (10/14). The median age was 67.1 years. Eleven (78.6%) patients experienced gradual onset of disease. Most patients presented nervous system lesions prior to occult tumors. The most common symptoms reported were proximal muscle weakness (92.9%), decreased or absent tendon reflexes (50%), and autonomic dysfunction (71.4%). All the patients showed reduction in action potential amplitude after repetitive peripheral never stimulation at low frequency and increased amplitude at high frequency. LEMS usually occurs prior to lung cancer with complicated and various clinical manifestations in our centers. We should improve awareness and knowledge of such disease to shorten the diagnostic delay and lead to few misdiagnoses.
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