期刊
CONTACT DERMATITIS
卷 87, 期 5, 页码 389-405出版社
WILEY
DOI: 10.1111/cod.14181
关键词
biocide; exposure; formaldehyde releaser; isothiazolinone; legislation; prevention; skin sensitization; temporal trend
The widespread use of skin sensitizing preservatives is well-known, but their use in non-cosmetic products is less recognized. This study reviewed EU legislations and analyzed data trends to find that the use of preservatives has significantly increased, posing a risk to health. Urgent action is needed to protect public health.
The widespread use of skin sensitizing preservatives is well-known. Contact allergy to preservatives is often caused by their presence in cosmetic products. Preservative use in non-cosmetic products is less well-known. We have reviewed European Union (EU) legislations on classification and labelling, biocides and cosmetics, concerning conditions for use of the most used sensitizing preservatives (including formaldehyde-releasing substances, isothiazolinones and parabens). We have analysed temporal trends in their use in non-cosmetic products (tonnes, number of products, concentrations), based on annual reports to the Swedish Products Register 1995-2018; and we discuss implications for stakeholders. Major changes over time are that the use of most of the preservatives has increased by tonnes and/or by number of products, and that several use concentrations have declined following harmonized classification as a skin sensitizer with low concentration limits for this classification. We conclude that the massive increase in use of preservatives is alarming, and that urgent action is needed for protection of health. Their use in non-cosmetic products is broad, increasing and often undisclosed. In the EU, legislations concerning chemicals can provide relevant restrictions to reduce their use and associated health risks, monitored by efficient surveillance. Prevention would be benefited by better coordination between legislations.
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