One-Pot Synthesis of Dysprosium Oxide Nano-Sheets: Antimicrobial Potential and Cyotoxicity on A549 Lung Cancer Cells

The present work deals with green synthesis of dysprosium oxide nano-sheets (Dy2O3 NS) using Syzygium travancoricum leaf extract. Synthesized NS were characterized by UV-VIS-DRS, ATR-FT-IR, PL, Raman spectroscopy, XRD, TEM with EDX and XPS analysis. UV-VIS-DRS analysis showed the absorption peak at 355 nm and band gap value of 4.8 eV. ATR-FT-IR analysis was performed to analyze the biomolecules responsible for formation of Dy2O3 NS. Micro-Raman analysis showed a peak at 373 cm(-1). XRD confirmed the presence of Dy2O3 NS with body-centered cubic structure. TEM images revealed the presence of nano sheets with size ranging from 100 to 200 nm and EDX analysis showed Dy and O elements and no other elements were detected, which indicates the purity of the resultant Dy2O3 NS. The synthesized Dy2O3 NS were tested against different bacterial and fungal species as well as cytotoxic agents on A549 lung cancer cells. The antimicrobial activity of Dy2O3 NS was significant on all the tested species. Cytotoxicity of Dy2O3 NS was revealed against A549 lung cancer cell lines in a dose-dependent manner. The results suggest that the synthesized Dy2O3 NS may be a promising candidate in the field of biomedical applications.