Bioactive polysaccharides and oligosaccharides from garlic (Allium sativum L.): Production, physicochemical and biological properties, and structure-function relationships

Garlic is a common food, and many of its biological functions are attributed to its components including functional carbohydrates. Garlic polysaccharides and oligosaccharides as main components are understudied but have future value due to the growing demand for bioactive polysaccharides/oligosaccharides from natural sources. Garlic polysaccharides have molecular weights of 1 x 10(3) to 2 x 10(6) Da, containing small amounts of pectins and fructooligosaccharides and large amounts of inulin-type fructans ((2 -> 1)-linked beta-d-Fruf backbones alone or with attached (2 -> 6)-linked beta-d-Fruf branched chains). This article provides a detailed review of research progress and identifies knowledge gaps in extraction, production, composition, molecular characteristics, structural features, physicochemical properties, bioactivities, and structure-function relationships of garlic polysaccharides/oligosaccharides. Whether the extraction processes, synthesis approaches, and modification methods established for other non-garlic polysaccharides are also effective for garlic polysaccharides/oligosaccharides (to preserve their desired molecular structures and bioactivities) requires verification. The metabolic processes of ingested garlic polysaccharides/oligosaccharides (as food ingredients/dietary supplements), their modes of action in healthy humans or populations with chronic conditions, and molecular/chain organization-bioactivity relationships remain unclear. Future research directions related to garlic polysaccharides/oligosaccharides are discussed.

Automated summary

Garlic polysaccharides and oligosaccharides, as the main functional carbohydrates in garlic, have future research value. This article provides a detailed review of research progress on garlic polysaccharides/oligosaccharides, and identifies knowledge gaps in extraction, composition, structural features, physicochemical properties, and bioactivities. Future research directions are also discussed.