期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 216, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112555
关键词
Metal-organic frameworks; Fe3O4; Heparin; pH-responsive; Magnetic targeting; Drug delivery system
资金
- Natural Science Foundation of Jiangsu Province [BK20200728]
- National Natural Sci-ence Foundation of China [22007049, 21702051]
- Jiangsu Innova-tion and Entrepreneurship Doctoral Program
- Jiangsu Specially-Appointed Professor Project
In this study, a delivery system for heparin was developed using magnetic composite materials, allowing for controlled, sustained, and targeted release. The composite exhibited high loading capacity and magnetic targeting capability, reducing systemic adverse effects and displaying excellent anticoagulant features.
Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications. Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8. The composite demonstrated a high loading capacity for the heparin, 66.8 mg/g. The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field. The anticoagulant activity was assessed by monitoring their activated partial thromboplastin time. The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations. Moreover, control over the dose exhibited excellent anticoagulant features with fewer side effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据