Phagocytic microglia and macrophages in brain injury and repair

Article Immunology

CD47 Blockade Accelerates Blood Clearance and Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage

Chao-ran Xu et al.

Summary: Anti-CD47 treatment has a neuroprotective effect after SAH, increasing blood clearance and reducing brain injury.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Endocrinology & Metabolism

Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ

Hongjian Pu et al.

Summary: IL-4 has been found to promote white matter integrity restoration and play a positive role in neurological recovery after TBI. However, IL-4 treatment did not reduce macroscopic brain lesions, but instead preserved white matter structure and function mainly through oligodendrogenesis.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

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Article Neurosciences

Neuroinflammatory inhibition of synaptic long-term potentiation requires immunometabolic reprogramming of microglia

Elisa M. York et al.

Summary: Immunometabolism refers to the restructuring of metabolic pathways in response to immune stimulation and their ability to control immune functions. By studying individual microglia within acute hippocampal slices, researchers found that LPS-induced glycolysis in microglia was necessary for stabilizing HIF-1 alpha and producing the proinflammatory cytokine IL-1 beta, which in turn inhibited the formation of synaptic LTP. Blunting microglial glycolysis with 2DG not only rescued LTP in LPS-stimulated slices but also inhibited HIF-1 alpha accumulation and IL-1 beta production. These findings highlight the importance of metabolic reprogramming in regulating microglial immune functions and their impact on cytokine release and neuronal activity.

GLIA (2021)

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Article Neurosciences

The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice

Xia Lei et al.

Summary: In this study, it was found that by activating the Nrf2 pathway, CDDO-EA can exert neuroprotective effects against ischemic injury, improving neurological function after cerebral ischemia, reducing infarct size and neuronal apoptosis, and modulating microglia/macrophage polarization towards an anti-inflammatory M2 phenotype.

CNS NEUROSCIENCE & THERAPEUTICS (2021)

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Article Cell Biology

Microglial 'fat shaming' in development and disease

Joanna Zareba et al.

Summary: Neuronal-immune interactions, especially involving microglia, play essential roles in brain development and health. Recent studies have shown that microglia exhibit a similar molecular signature in development and disease, with a focus on genes related to phagocytosis, lipid uptake, and metabolism. Accumulation of cholesterol and lipid-rich debris in microglia in neurodegenerative conditions suggests lipid processing and transport as potential therapeutic targets.

CURRENT OPINION IN CELL BIOLOGY (2021)

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Article Neurosciences

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Stefan A. Berghoff et al.

Summary: The study reveals that sterol synthesis in microglia/macrophages is crucial for resolving inflammation and inducing remyelination in the repair of demyelinated lesions in multiple sclerosis (MS), with desmosterol activating LXR signaling as a key mechanism.

NATURE NEUROSCIENCE (2021)

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Article Neurosciences

MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization

Yong-Yue Gao et al.

Summary: The study found that rhMFG-E8 can inhibit brain edema, improve neurological function, reduce inflammatory factor levels, and promote microglial transformation to the M2 phenotype. However, inhibition of MFG-E8 and integrin beta 3 via specific siRNA, as well as the STAT3 inhibitor Stattic, can abolish the effects of MFG-E8 on anti-inflammation and M2 phenotype polarization.

EXPERIMENTAL NEUROLOGY (2021)

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Review Biochemistry & Molecular Biology

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

Claire A. Butler et al.

Summary: Recent evidence suggests that excessive microglial phagocytosis of live neurons and synapses contributes to neurodegeneration in animal models of various brain diseases. Factors regulating microglial phagocytosis of neurons could be potential treatment targets to prevent neurodegeneration induced by excessive microglial phagocytosis of live neurons and synapses.

JOURNAL OF NEUROCHEMISTRY (2021)

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Review Immunology

Biological Functions and Regulatory Mechanisms of Hypoxia-Inducible Factor-1α in Ischemic Stroke

Qianyan He et al.

Summary: Ischemic stroke, caused by inadequate cerebrovascular blood and oxygen supply, poses a significant global health burden. HIF-1α, a key regulator of oxygen homeostasis, plays a critical role in various aspects of stroke pathophysiology and is an important target for potential therapeutic interventions. Further research into the differential regulation of HIF-1α in different cell types during ischemic stroke is crucial for understanding the disease mechanism and identifying novel treatment strategies.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Microglia use TAM receptors to detect and engulf amyloid β plaques

Youtong Huang et al.

Summary: The TAM receptor kinases are found to be essential for microglial recognition and engulfment of amyloid plaques in Alzheimer's disease, with their phagocytosis actually promoting the formation of dense-core plaques. This study also reveals that Axl and Mer play crucial roles in microglial response to amyloid plaques, and their deficiency leads to impaired detection, response, organization, and phagocytosis of amyloid-beta plaques.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Xin Ding et al.

Summary: Microglial SIRP alpha regulates synaptic pruning during development. Its role in neurodegeneration is unclear. Here, the authors show that microglial SIRP alpha declines in the model of Alzheimer's disease, leading to excessive microglia mediated synapse elimination as well as impaired cognitive function.

NATURE COMMUNICATIONS (2021)

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Article Neurosciences

Anti-CD47 antibody administration via cisterna magna in proper dosage can reduce perihematomal cell death following intracerebral hemorrhage in rats

Yan Song et al.

Summary: This study demonstrated that administration of an appropriate dosage (0.9 µg) of anti-CD47 antibody via the cisterna magna after intracerebral hemorrhage can effectively reduce cell death, increase MG/Mo aggregation, and facilitate hematoma clearance.

BRAIN RESEARCH BULLETIN (2021)

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Review Neurosciences

New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery

Fang Yu et al.

Summary: This passage discusses the interaction between microglial activation and endogenous neuroplasticity, focusing on plastic alterations in the overall brain network and their implications for structural and functional restoration after stroke. It also summarizes recent advances in the impacts of microglial phenotype polarization on brain plasticity, aiming to discuss the potential efficacy of microglia-based extrinsic restorative interventions in promoting post-stroke recovery.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Immunology

CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity

Vanessa Aires et al.

Summary: The study identified CD22 as a broad age-associated modulator of microglia functionality, with stronger effects in aged microglia. Blocking CD22 improved surveillance capacity in aged mice, without affecting adult mice. Additionally, human iPSC-derived macrophages showed increased phagocytic capacity upon CD22 blockage.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Phagocytic Code Regulating Phagocytosis of Mammalian Cells

Tom O. J. Cockram et al.

Summary: Mammalian phagocytes can eat other mammalian cells in the body based on specific signals, and understanding the phagocytic code could lead to novel therapies for various diseases involving faulty phagocytosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair

Eslam M. F. Mehina et al.

Summary: The study identified a unique population of Gal3-expressing infiltrative macrophages in diabetic mice that play a crucial role in promoting vessel elimination after brain injury. Depletion of these infiltrative macrophages attenuated phagocytic activity and prevented the loss of blood vessels after injury.

SCIENCE ADVANCES (2021)

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Article Endocrinology & Metabolism

RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke

Rongrong Wang et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Article Endocrinology & Metabolism

Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery

Lu Jiang et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Article Immunology

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

Maria Ines Cunha et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Neurosciences

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Julia Marschallinger et al.

NATURE NEUROSCIENCE (2020)

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Review Biochemistry & Molecular Biology

Toll-like Receptors and the Control of Immunity

Katherine A. Fitzgerald et al.

CELL (2020)

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Article Neurosciences

P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis

Ruo-Xue Wen et al.

CNS NEUROSCIENCE & THERAPEUTICS (2020)

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Article Neurosciences

Carbon monoxide controls microglial erythrophagocytosis by regulating CD36 surface expression to reduce the severity of hemorrhagic injury

Sandra Kaiser et al.

GLIA (2020)

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Article Endocrinology & Metabolism

Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia

Ligen Shi et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Article Neurosciences

Defining molecular identity and fates of CNS-border associated macrophages after ischemic stroke in rodents and humans

Wenson D. Rajan et al.

NEUROBIOLOGY OF DISEASE (2020)

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Review Clinical Neurology

The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development

Kristy A. Zera et al.

NEUROTHERAPEUTICS (2020)

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Article Cell Biology

Aging and sex: Impact on microglia phagocytosis

Natalia Yanguas-Casas et al.

AGING CELL (2020)

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Article Neurosciences

DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke

Ludmila Belayev et al.

CNS NEUROSCIENCE & THERAPEUTICS (2020)

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Article Biochemistry & Molecular Biology

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

Phi T. Nguyen et al.

CELL (2020)

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Article Immunology

TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model

Yijie Zhang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Neurosciences

Microglia phagocytose myelin sheaths to modify developmental myelination

Alexandria N. Hughes et al.

NATURE NEUROSCIENCE (2020)

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Review Neurosciences

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

Mar Puigdellivol et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Review Endocrinology & Metabolism

Regulation of blood-brain barrier integrity by microglia in health and disease: A therapeutic opportunity

Patrick T. Ronaldson et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Review Endocrinology & Metabolism

Neuroinflammatory responses of microglia in central nervous system trauma

Donald C. Shields et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Review Neurosciences

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease

Joseph W. Lewcock et al.

NEURON (2020)

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Article Multidisciplinary Sciences

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

Zhaohui Chen et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

Jing Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Medicine, Research & Experimental

Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion

Lin-Yuan Zhang et al.

THERANOSTICS (2020)

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Article Multidisciplinary Sciences

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

Takahiro Masuda et al.

NATURE (2019)

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Review Cardiac & Cardiovascular Systems

Neuroimmune crosstalk in the pathophysiology of hypertension

Laura Calvillo et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Article Multidisciplinary Sciences

Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation

Cheng-Fang Hsieh et al.

SCIENTIFIC REPORTS (2019)

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Article Multidisciplinary Sciences

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

John V. Pluvinage et al.

NATURE (2019)

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Article Neurosciences

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van Hove et al.

NATURE NEUROSCIENCE (2019)

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Review Neurosciences

Dual Functions of Microglia in Ischemic Stroke

Chuan Qin et al.

NEUROSCIENCE BULLETIN (2019)

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Article Cell Biology

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

Sung Hoon Baik et al.

CELL METABOLISM (2019)

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Article Clinical Neurology

Enhancement of Hematoma Clearance With CD47 Blocking Antibody in Experimental Intracerebral Hemorrhage

Chaohui Jing et al.

STROKE (2019)

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Review Immunology

Phagocytosis in the Brain: Homeostasis and Disease

Dylan A. Galloway et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke

Pascal Gervois et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell Biology

Siglecs in Brain Function and Neurological Disorders

Shoib Sarwar Siddiqui et al.

CELLS (2019)

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Article Neurosciences

Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain

Wenting Zhang et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

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Review Neurosciences

Sexually dimorphic microglia and ischemic stroke

Nadine Kerr et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

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Review Neurosciences

Update of inflammasome activation in microglia/macrophage in aging and aging-related disease

Meng-yan Hu et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

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Review Immunology

Complement dysregulation in the central nervous system during development and disease

John D. Lee et al.

SEMINARS IN IMMUNOLOGY (2019)

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Article Clinical Neurology

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

Amaia Otxoa-de-Amezaga et al.

ACTA NEUROPATHOLOGICA (2019)

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Editorial Material Neurosciences

Microglia/macrophage diversities in central nervous system physiology and pathology

Di Xie et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

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Article Immunology

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

Gerard Elberg et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Medicine, Research & Experimental

STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice

Wei Cai et al.

JCI INSIGHT (2019)

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Review Biochemistry & Molecular Biology

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease

Anna Vilalta et al.

FEBS JOURNAL (2018)

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Article Medicine, Research & Experimental

Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage

Che-Feng Chang et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Immunology

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

Sofia Pavlou et al.

BMC IMMUNOLOGY (2018)

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Article Immunology

Absence of microglial CX3CR1 impairs the synaptic integration of adult-born hippocampal granule neurons

M. Bolos et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

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Article Immunology

Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke

K. A. Jones et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

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Review Respiratory System

Targeting the interleukin-4 and interleukin-13 pathways in severe asthma: current knowledge and future needs

Amit D. Parulekar et al.

CURRENT OPINION IN PULMONARY MEDICINE (2018)

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Review Neurosciences

Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks

Ioanna Sandvig et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2018)

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Review Immunology

Human dendritic cell subsets: an update

Matthew Collin et al.

IMMUNOLOGY (2018)

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Article Neurosciences

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

Wei Cai et al.

PROGRESS IN NEUROBIOLOGY (2018)

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Review Medical Laboratory Technology

Macrophages under pressure: the role of macrophage polarization in hypertension

Sailesh C. Harwani

TRANSLATIONAL RESEARCH (2018)

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Article Multidisciplinary Sciences

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Laetitia Weinhard et al.

NATURE COMMUNICATIONS (2018)

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Article Immunology

Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids

Michael Heming et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Clinical Neurology

Diabetes Mellitus Impairs White Matter Repair and Long-Term Functional Deficits After Cerebral Ischemia

Shubei Ma et al.

STROKE (2018)

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Review Neurosciences

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

Hiroyuki Konishi et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Multidisciplinary Sciences

Programmed cell removal by calreticulin in tissue homeostasis and cancer

Mingye Feng et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Silencing of TGFβ signalling in microglia results in impaired homeostasis

Tanja Zoeller et al.

NATURE COMMUNICATIONS (2018)

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Article Neurosciences

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

Emily K. Lehrman et al.

NEURON (2018)

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Article Biochemistry & Molecular Biology

Neutrophil granulocytes in cerebral ischemia - Evolution from killers to key players

Jan-Kolja Strecker et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

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Article Neurosciences

CD47 deficiency improves neurological outcomes of traumatic brain injury in mice

Song Zhao et al.

NEUROSCIENCE LETTERS (2017)

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Review Physiology

The role of macrophages in hypertension and its complications

A. Justin Rucker et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)

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Article Neurosciences

The biphasic function of microglia in ischemic stroke

Yuanyuan Ma et al.

PROGRESS IN NEUROBIOLOGY (2017)

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Article Medicine, Research & Experimental

M2 Phenotype Microglia-derived Cytokine Stimulates Proliferation and Neuronal Differentiation of Endogenous Stem Cells in Ischemic Brain

Ja Yong Choi et al.

EXPERIMENTAL NEUROBIOLOGY (2017)

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Article Multidisciplinary Sciences

Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration

Ping Kei Yip et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Manuel J. Del Rey et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Hadas Keren-Shaul et al.

CELL (2017)

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Review Critical Care Medicine

Blood pressure control for acute severe ischemic and hemorrhagic stroke

Julian Boesel

CURRENT OPINION IN CRITICAL CARE (2017)

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Review Chemistry, Multidisciplinary

Regulation of microglial activation in stroke

Shou-cai Zhao et al.

ACTA PHARMACOLOGICA SINICA (2017)

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Article Immunology

Origin, fate and dynamics of macrophages at central nervous system interfaces

Tobias Goldmann et al.

NATURE IMMUNOLOGY (2016)

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Article Neurosciences

Age-related myelin degradation burdens the clearance function of microglia during aging

Shima Safaiyan et al.

NATURE NEUROSCIENCE (2016)

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Article Multidisciplinary Sciences

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

Won-Suk Chung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Clinical Neurology

Role of Erythrocyte CD47 in Intracerebral Hematoma Clearance

Wei Ni et al.

STROKE (2016)

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Article Multidisciplinary Sciences

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

G. O. Sipe et al.

NATURE COMMUNICATIONS (2016)

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Article Clinical Neurology

TREM2 regulates microglial cell activation in response to demyelination in vivo

Claudia Cantoni et al.

ACTA NEUROPATHOLOGICA (2015)

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Article Neurosciences

How microglia kill neurons

Guy C. Brown et al.

BRAIN RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

Yuka Atagi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Review Endocrinology & Metabolism

Targeting neutrophils in ischemic stroke: translational insights from experimental studies

Glen C. Jickling et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

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Article Medicine, Research & Experimental

TREM2 sustains microglial expansion during aging and response to demyelination

Pietro Luigi Poliani et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Immunology

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

Antoine Lampron et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

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Article Immunology

Functional differences between microglia and monocytes after ischemic stroke

Rodney M. Ritzel et al.

JOURNAL OF NEUROINFLAMMATION (2015)

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Review Neurosciences

Immune attack: the role of inflammation in Alzheimer disease

Frank L. Heppner et al.

NATURE REVIEWS NEUROSCIENCE (2015)

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Article Clinical Neurology

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

Valerie Jolivel et al.

ACTA NEUROPATHOLOGICA (2015)

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Article Biochemistry & Molecular Biology

Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance

Xiurong Zhao et al.

JOURNAL OF NEUROCHEMISTRY (2015)

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Article Neurosciences

Inhibition of UDP/P2Y6 Purinergic Signaling Prevents Phagocytosis of Viable Neurons by Activated Microglia In Vitro and In Vivo

Jonas J. Neher et al.

GLIA (2014)

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Article Neurosciences

Toll-Like Receptor 4 Deficiency Impairs Microglial Phagocytosis of Degenerating Axons

Labchan Rajbhandari et al.

GLIA (2014)

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Article Immunology

CD36-Mediated Hematoma Absorption following Intracerebral Hemorrhage: Negative Regulation by TLR4 Signaling

Huang Fang et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Cell Biology

Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR γ and 5-LO-dependent pathways

Ivan Ballesteros et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2014)

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Article Immunology

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

Zhiwei Tang et al.

JOURNAL OF NEUROINFLAMMATION (2014)

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Review Immunology

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Jonathan D. Cherry et al.

JOURNAL OF NEUROINFLAMMATION (2014)

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Review Clinical Neurology

Microglial priming in neurodegenerative disease

V. Hugh Perry et al.

NATURE REVIEWS NEUROLOGY (2014)

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Article Neurosciences

Microglial phagocytosis of live neurons

Guy C. Brown et al.

NATURE REVIEWS NEUROSCIENCE (2014)

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Review Biochemistry & Molecular Biology

Phosphatidylserine in the brain: Metabolism and function

Hee-Yong Kim et al.

PROGRESS IN LIPID RESEARCH (2014)

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Review Neurosciences

Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles

Xiaoming Hu et al.

PROGRESS IN NEUROBIOLOGY (2014)

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Review Neurosciences

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

Dorothy P. Schafer et al.

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