4.3 Review

Landscape of coronavirus disease 2019 clinical trials: New frontiers and challenges

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Letter Medicine, General & Internal

Comparison of mRNA-1273 and BNT162b2 Vaccines on Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Death During the Delta-Predominant Period

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Summary: Ivermectin has become a controversial potential medicine for COVID-19. Early studies suggested its clinical benefits in treating the infection, but the quality of evidence varies and some trials may be fraudulent. A subgroup meta-analysis reveals that the significant effect of ivermectin on survival is mainly observed in poor-quality studies.

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Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study

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Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19 A Systematic Review and Meta-analysis

Perrine Janiaud et al.

Summary: Convalescent plasma treatment showed no significant decrease in all-cause mortality or benefit for other clinical outcomes compared to placebo or standard of care. The certainty of the evidence ranged from low to moderate for all-cause mortality and remained low for other outcomes.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

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Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

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Summary: There is currently no evidence-based treatment for COVID-19. Some medications may help reduce the risk of death, serious adverse events, and mechanical ventilation, but with very low certainty. More trials with low risks of bias and random errors are urgently needed for COVID-19 treatment.

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Summary: The summary highlights the experiences of 15 organizations in dealing with uncoordinated efforts during the COVID-19 pandemic, focusing on electronic health record data and proposing specific strategic next steps to increase interoperability, overall organization, and efficiencies.

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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

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John H. Beigel et al.

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Risk for In-Hospital Complications Associated with COVID-19 and Influenza - Veterans Health Administration, United States, October 1, 2018-May 31, 2020

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Donald A. Berry et al.

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Review Medicine, General & Internal

Ethnicity and clinical outcomes in COVID-19: A systematic review and meta-analysis

Shirley Sze et al.

ECLINICALMEDICINE (2020)

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Adaptive Randomization of Neratinib in Early Breast Cancer

J. W. Park et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Editorial Material Medicine, General & Internal

I-SPY 2-Toward More Rapid Progress in Breast Cancer Treatment

Lisa A. Carey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Medicine, Research & Experimental

Adaptive Clinical Trial Design

Shein-Chung Chow

ANNUAL REVIEW OF MEDICINE, VOL 65 (2014)

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The ClinicalTrials.gov Results Database - Update and Key Issues

Deborah A. Zarin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Critical Care Medicine

ViEWS-Towards a national early warning score for detecting adult inpatient deterioration

David R. Prytherch et al.

RESUSCITATION (2010)