4.7 Article

Preclinical Development of [211At]meta- astatobenzylguanidine ([211At]MABG) as an Alpha Particle Radiopharmaceutical Therapy for Neuroblastoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Anatomic patterns of relapse and progression following treatment with 131I-MIBG in relapsed or refractory neuroblastoma

Rotem Fishel Ben Kenan et al.

Summary: Previously involved anatomic disease sites predominate at disease progression following I-131-MIBG treatment. Nevertheless, the majority of patients progressed in at least one new anatomic disease site. This suggests that consolidation focal therapies targeting residual disease sites may be of limited benefit in preventing systemic disease progression following I-131-MIBG treatment of relapsed or refractory neuroblastoma.

PEDIATRIC BLOOD & CANCER (2022)

Article Oncology

Radiopharmaceutical Chemistry and Drug Development-What's Changed?

Charles A. Kunos et al.

Summary: Radiation oncologists and nuclear medicine physicians have observed a resurgence in the clinical use of radiopharmaceuticals for cancer treatment. The United States National Cancer Institute has adapted its clinical trial enterprise to facilitate the discovery and development of new targeted radiopharmaceutical treatments, viewing investigational radiopharmaceuticals as drugs with maximum tolerable doses determined by normal organ toxicity frequency. This shift in perspective has led to the emergence of alpha-particle and beta-particle emitters as a significant approach to cancer treatment, with resources allocated to biomarkers of molecular pathophysiology now used to select treatment or evaluate clinical performance of radiopharmaceuticals.

SEMINARS IN RADIATION ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The Hopeful Eight

Romain Eychenne et al.

Summary: This review summarizes the main properties of eight selected radionuclides, including their production process, chemical behavior, and biological evaluations, discussing the entire process from their availability to clinical studies.

PHARMACEUTICS (2021)

Review Medicine, General & Internal

Revisiting the Radiobiology of Targeted Alpha Therapy

Jean-Pierre Pouget et al.

Summary: Targeted alpha therapy using alpha particle-emitting radionuclides is highly cytotoxic and suitable for small-volume tumors. Clinical studies showed that alpha particles might also be effective in large tumors, and biological effects have been observed away from irradiated cells.

FRONTIERS IN MEDICINE (2021)

Article Oncology

Realizing Clinical Trials with Astatine-211: The Chemistry Infrastructure

Sture Lindegren et al.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2020)

Review Biotechnology & Applied Microbiology

Radiopharmaceutical therapy in cancer: clinical advances and challenges

George Sgouros et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Intraperitoneal α-Emitting Radioimmunotherapy with 211At in Relapsed Ovarian Cancer: Long-Term Follow-up with Individual Absorbed Dose Estimations

Andreas Hallqvist et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

Review Biochemistry & Molecular Biology

Development of Targeted Alpha Particle Therapy for Solid Tumors

Narges K. Tafreshi et al.

MOLECULES (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Antitumor effects of radionuclide treatment using α-emitting meta-211At-astato-benzylguanidine in a PC12 pheochromocytoma model

Yasuhiro Ohshima et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2018)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, General & Internal

Neuroblastoma

Katherine K. Matthay et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Oncology

Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma

JulieAnn Rader et al.

CLINICAL CANCER RESEARCH (2013)

Review Radiology, Nuclear Medicine & Medical Imaging

Preclinical Assessment of Strategies for Enhancement of Metaiodobenzylguanidine Therapy of Neuroendocrine Tumors

Rob J. Mairs et al.

SEMINARS IN NUCLEAR MEDICINE (2011)

Review Radiology, Nuclear Medicine & Medical Imaging

MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy

George Sgouros et al.

JOURNAL OF NUCLEAR MEDICINE (2010)

Review Medicine, General & Internal

Medical Progress: Recent Advances in Neuroblastoma.

John M. Maris

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Radiology, Nuclear Medicine & Medical Imaging

Intraperitoneal α-Particle Radioimmunotherapy of Ovarian Cancer Patients: Pharmacokinetics and Dosimetry of 211At-MX35 F(ab′)2-A Phase I Study

Hakan Andersson et al.

JOURNAL OF NUCLEAR MEDICINE (2009)

Review Radiology, Nuclear Medicine & Medical Imaging

Radiolabeled metaiodobenzylguanidine for the treatment of neuroblastoma

Steven G. DuBois et al.

NUCLEAR MEDICINE AND BIOLOGY (2008)

Article Pharmacology & Pharmacy

Astatine Radiopharmaceuticals: Prospects and Problems

Ganesan Vaidyanathan et al.

CURRENT RADIOPHARMACEUTICALS (2008)

Article Oncology

The pediatric preclinical testing program: Description of models and early testing results

Peter J. Houghton et al.

PEDIATRIC BLOOD & CANCER (2007)

Article Biochemistry & Molecular Biology

A kit method for the high level synthesis of [211At]MABG

Ganesan Vaidyanathan et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Radiology, Nuclear Medicine & Medical Imaging

Local delivery of 131I-MIBG to treat peritoneal neuroblastoma

S Kinuya et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2003)