4.7 Article

PD-1T TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Multidisciplinary Sciences

Tertiary lymphoid structures in cancer

Ton N. Schumacher et al.

Summary: This article discusses the current knowledge on TLSs in cancer, focusing on the drivers of TLS formation, the function and contribution of TLSs to the antitumor immune response, and the potential of TLSs as therapeutic targets in human cancers.

SCIENCE (2022)

Article Multidisciplinary Sciences

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Justina X. Caushi et al.

Summary: Single-cell RNA sequencing and T cell receptor sequencing are combined to identify transcriptional programs specific to mutation-associated neoantigen-specific T cells in non-small cell lung cancers treated with anti-PD-1, providing insights into resistance to PD-1 blockade.

NATURE (2021)

Article Multidisciplinary Sciences

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

Giacomo Oliveira et al.

Summary: The authors demonstrate through single-cell profiling and T cell receptor specificity screening that tumour antigen recognition influences the phenotypes of CD8(+) T cells and antitumour immune responses. Non-tumour-reactive T cells show a non-exhausted memory phenotype, while melanoma-reactive lymphocytes exhibit an exhausted state, providing insights into the properties of the anti-melanoma TCR repertoire.

NATURE (2021)

Article Biochemistry & Molecular Biology

An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer

Paula Voabil et al.

Summary: A study using patient-derived tumor fragments as an ex vivo platform showed that the reactivation of tumor-infiltrating immune cells after PD-1 blockade could predict clinical outcomes. Tumor-resident T cells were identified as crucial in the immunological response, and a subgroup of tumors was found to be unresponsive to PD-1 blockade. Additionally, the presence of tertiary lymphoid structures in baseline tumors correlated with the capacity for intratumoral immune cell reactivation.

NATURE MEDICINE (2021)

Article Multidisciplinary Sciences

B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

Review Oncology

CD8+ T cell states in human cancer: insights from single-cell analysis

Anne M. Van der Leun et al.

NATURE REVIEWS CANCER (2020)

Review Oncology

Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC

D. Ross Camidge et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Article Oncology

Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy

Sonja Althammer et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Article Oncology

Lesion-Level Response Dynamics to Programmed Cell Death Protein (PD-1) Blockade

Juan C. Osorio et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Review Oncology

Tertiary lymphoid structures in the era of cancer immunotherapy

Catherine Sautes-Fridman et al.

NATURE REVIEWS CANCER (2019)

Article Cell Biology

Digital image analysis improves precision of PD-L1 scoring in cutaneous melanoma

Viktor H. Koelzer et al.

HISTOPATHOLOGY (2018)

Review Medicine, General & Internal

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

Michael A. Postow et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Keith E. Steele et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Article Medicine, General & Internal

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Martin Reck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer

Edward B. Garon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer

Julie Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

H. Borghaei et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)