期刊
CLINICAL BREAST CANCER
卷 22, 期 7, 页码 E788-E797出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clbc.2022.07.001
关键词
Breast cancer; Estrogen receptor; Progesterone receptor; Relapse-free survival; Disease-specific survival
类别
Approximately 12% of breast cancers have an estrogen receptor-positive/progesterone receptor-negative phenotype. These tumors have different clinicopathologic features compared to other types of breast cancers and are generally associated with a worse prognosis.
Approximately 12% of breast cancers have an estrogen receptor-positive/progesterone receptor-negative (ER+/PR-) phenotype. The prognosis of ER+/PR- tumors is intermediate to that between ER+/PR+ and ER/PR- tumors. A near-maximal ER expression is needed to compensate for the altered ER signaling in ER/PRtumors. Background: While most estrogen receptor-positive (ER+) breast cancers express progesterone receptor (PR), a small subset of tumors exhibits an ER+/PR- phenotype despite the fact that PR is an ER-dependent gene product. Previous studies have shown that these tumors are generally associated with a worse clinical outcome when compared to the ER+/PR+ breast cancers, indicating that they are clinically and probably genetically different entities. Methods: We characterized the clinicopathologic features of ER+/PR- tumors from the Surveillance, Epidemiology and End Results (SEER) database and the authors' institutional cohort. Results: ER+/PR- tumors, constituting 12% of all breast cancers in both cohorts, less frequently occurred in Caucasians, were more likely to be of a higher histologic grade and presented with a higher stage when compared to ER+/PR+ tumors. Conversely, ER+/PR- neoplasms were more frequently seen in Caucasians, less likely to be of a higher histologic grade and less frequently presented with an advanced clinical stage when compared to ER-/PR- tumors. Further, the ER+/PR- tumors were associated with a disease-specific survival intermediate to that between ER +/PR + and ER-/PR- tumors. An ER H-score of >= 270 was associated with a significantly superior relapse-free survival in the ER+/PR- tumors, suggesting that a near-maximal ER expression is needed to compensate for the altered ER signaling in these tumors. Pathologic stage and HER2 status were independent prognostic factors in the ER+/PR- tumors. These findings may provide additional insights in directing clinical decision making for individualized systemic therapy in the pursuit of precision medicine.
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