A Pd2L4 Metallacage-Cored Supramolecular Amphiphile and Its Application in Dual-Responsive Controllable Release†

Comprehensive Summary The construction of multi-responsive supramolecular systems for drug delivery is a challenging task. In this work, a Pd2L4 metallacage 1 center dot([BF4](-))(4) with four pyrene units was first designed and synthesized through coordination-driven self-assembly. After the introduction of gamma-CD, a supramolecular amphiphile 1-gamma-CD was successfully constructed based on the host-guest molecular recognition between gamma-CD and the pyrene unit of 1 center dot([BF4](-))(4), which further self-assembled into dual-responsive supramolecular vesicles in aqueous solution. DOX center dot HCl was used as a model molecule to study the drug encapsulation and release behavior of the supramolecular vesicles. By adjusting the pH of the solution to acidic condition or adding a certain amount of alpha-amylase, the vesicle structure was destroyed to achieve rapid and effective release of the drug molecules. This study provides an example for the rational design of efficient dual-responsive supramolecular nanocarriers, which have potential application value in the field of controlled drug delivery.

Automated summary

In this study, a Pd2L4 metallacage with four pyrene units was successfully synthesized through coordination-driven self-assembly, and a supramolecular amphiphile was constructed based on host-guest molecular recognition. The supramolecular vesicles showed dual-responsive behavior and achieved rapid and effective drug release by adjusting the pH or adding a certain amount of alpha-amylase.