期刊
JOURNAL OF CLINICAL SLEEP MEDICINE
卷 12, 期 4, 页码 571-578出版社
AMER ACAD SLEEP MEDICINE
DOI: 10.5664/jcsm.5694
关键词
cohort; depression; hypersomnolence; mood disorders; multiple sleep latency test; sleepiness
资金
- National Institute of Mental Health [K23MH099234]
- National Heart, Lung, and Blood Institute [R01HL62252]
- National Institute of Aging [R01AG14124]
- National Institute of Neurological Disorders and Stroke [NIH-NS23724]
- National Center for Research Resources at the US National Institutes of Health [1UL1RR025011]
- Brain and Behavior Research Foundation
- American Sleep Medicine Foundation
- University of Wisconsin School of Medicine and Public Health
- Merck
- GSK
Study Objectives: To examine associations of depression with habitual sleep duration, daytime sleepiness, and objective sleep propensity in a nonclinical population. Methods: Data from adults participating in the Wisconsin Sleep Cohort Study were utilized in analyses. There were 1,287 adults (3,324 observations) who were used in the analysis of subjective hypersomnolence measures; 1,155 adults (2,981 observations) were used in the analysis of objective sleep propensity assessed by the multiple sleep latency test (MSLT). Repeated-measures logistic regression estimated associations between presence of depression (defined as modified Zung Self-Rating Depression Scale >= 50 or use of antidepressant medications) and three primary hypersomnolence measures: subjective excessive daytime sleepiness (Epworth Sleepiness Scale [ESS] >= 11), self-reported sleep duration >= 9 h/d, and objective sleep propensity (MSLT mean sleep latency < 8 min). Results: After adjusting for age, sex, body mass index, chronic medical conditions, sedative hypnotic medication use, caffeine, tobacco, and alcohol use, sleep disordered breathing, as well as insomnia and sleep duration when appropriate, estimated odd ratios (95% confidence interval) for depression were: 1.56 (1.31,1.86) for ESS >= 11; 2.01 (1.49, 2.72) for habitual sleep time >= 9 h; and 0.76 (0.63-0.92) for MSLT mean sleep latency < 8 min. Conclusions: Our results demonstrate divergent associations between subjective and objective symptoms of hypersomnolence and depression, with subjective sleepiness and excessive sleep duration associated with increased odds of depression, but objective sleep propensity as measured by the MSLT associated with decreased odds of depression. Further research is indicated to explain this paradox and the impact of different hypersomnolence measures on the course of mood disorders.
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