Silver-Promoted Decarboxylative Difluoromethylenation of α,β-Unsaturated Carboxylic Acids for the Synthesis of Allylic Difluorides

An efficient silver-promoted decarboxylative gem-difluoromethylenation of aryl- or alkyl-substituted alpha,beta-unsaturated carboxylic acids with readily available benzo-1,3-diazolic difluoromethyl bromides has been developed. This convenient transformation demonstrated good functional-group tolerability and broad substrate scope, and afforded the allylic difluorides in good to excellent yields with exclusive E-stereoselectivity under mild reaction conditions.

Automated summary

An efficient and convenient method for the synthesis of allylic difluorides has been developed. The reaction demonstrated good functional-group tolerance, broad substrate scope, and excellent diastereoselectivity.