期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 17, 期 19, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200619
关键词
Coumarin; Hydrolysis; Decarboxylative Heck reaction; 2-Hydroxystilbene
资金
- CSIR/UGC New Delhi [10442]
This study successfully developed a method for synthesizing 2-hydroxystilbene derivatives, using hydrolysis of natural coumarins followed by in situ decarboxylative Heck coupling with haloarenes. The reaction conditions were fine-tuned to exclusively produce 2-hydroxystyrylbenzenes, avoiding the formation of other possible side products such as benzofuran or substituted coumarins.
The 2-hydroxystyrylbenzene scaffold is found in various compounds that are widely applicable in medicinal chemistry as well as material chemistry. Here, a successful attempt is made to develop a one-pot protocol for the synthesis of 2-hydroxystilbene derivatives via hydrolysis of natural coumarins followed by in situ decarboxylative Heck coupling with haloarenes. Fine tuning of the reaction conditions allowed exclusive formation of 2-hydroxystyrylbenzenes over other possible side products, i. e., benzofuran/substituted coumarins.
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