期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 17, 期 15, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200397
关键词
F-19 magnetic resonance imaging; hydrophilic fluorine fragment; self-assembly; surface functionalization
资金
- National Natural Science Foundation of China [21874007]
- Beijing Municipal Natural Science Foundation [2212011]
- Fundamental Research Funds for the Central Universities [PY2101]
A novel molecule (CFO) nanoprobe was developed for in-vivo F-19 MRI and could serve as a general fluorine labeling agent for surface functionalization of nanoparticles, providing a universal method for constructing water-soluble multifunctional nanoplatforms.
The development of multifunctional nanoplatforms for bioimaging and therapy has attracted extensive attention in recent decades. As an emerging magnetic resonance imaging (MRI) technique, F-19 MRI effectively complements the limit of H-1 MRI owing to trace amount of F-19 atoms existing in the human body, affording high specificity. In this work, a novel molecule (CFO) containing hydrophilic fluorine fragments was synthesized using amino acids as starting materials, which could self-assemble into small nanoprobes via hydrophobic interactions of oleic acid moiety. The as-prepared nanoprobes displayed good relaxation performances thanks to the carboxylate group and sulfoxide group nearby. The nanoprobes successfully demonstrated its capacity for in-vivo F-19 MRI. In addition, CFO could be used as a general fluorine labeling agent for surface functionalization of nanoparticles, which provided a universal method for constructing water-soluble multifunctional nanoplatforms.
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