New Opportunities for the Utilization of the Sulfoximine Group in Medicinal Chemistry from the Drug Designer's Perspective

Extension of the medicinal chemistry toolbox is in the vital interest of drug designers. However, the diffusion of an innovation can be a lengthy process. Along these lines, it took almost 70 years before the use of the sulfoximine group reached a critical mass in medicinal chemistry. Even though interest in this versatile functional group has increased exponentially in recent years, there is ample room for further innovative applications. This Review highlights emerging trends and opportunities for drug designers for the utilization of the sulfoximine group in medicinal chemistry, such as in the construction of complex molecules, proteolysis targeting chimeras (PROTACs), antibody-drug conjugates (ADCs) and novel warheads for covalent inhibition.

Automated summary

This article highlights the emerging trends and opportunities for drug designers to utilize the sulfoximine group in medicinal chemistry, such as in the construction of complex molecules, PROTACs, ADCs, and novel warheads for covalent inhibition. Despite the increasing interest in the sulfoximine group in recent years, there is still ample room for further innovative applications.